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Usage

Uses

Used in Pharmaceutical Industry:
N-TERT-BUTYL-N'-METHYL ETHYLENEDIAMINE is used as a catalyst for the synthesis of various pharmaceutical compounds. Its ability to facilitate the formation of carbon-carbon and carbon-nitrogen bonds makes it an essential component in the production of a wide range of medications.
Used in Pesticide Industry:
N-TERT-BUTYL-N'-METHYL ETHYLENEDIAMINE is used as a catalyst in the production of pesticides. Its reactivity and ability to promote bond formation contribute to the synthesis of effective and efficient pest control agents.
Used in Industrial Chemical Production:
N-TERT-BUTYL-N'-METHYL ETHYLENEDIAMINE is used as a catalyst for the synthesis of various industrial chemicals. Its versatility in facilitating bond formation makes it a valuable component in the production of a broad spectrum of chemical products.
It is important to handle N-TERT-BUTYL-N'-METHYL ETHYLENEDIAMINE with care in a controlled laboratory setting due to its highly reactive nature.

Upstream product

• 74-89-5 methylamine 
• 123387-72-4 O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate 
• 75-64-9 tert-butylamine 

Relevant academic research and scientific papers

Steric and electronic effects in the dimerization of Wanzlick carbenes: The alkyl effect

The steric and electronic influence of N-alkyl substituents on the dimerization energies ΔG° of Wanzlick carbenes (imidazolidin-2- ylidenes) was investigated experimentally and through DFT methods for a series of non-symmetrically substituted Wanzlick carbenes. A series of 3-alkyl-1-tert-butylimidazolidin-2-ylidenes with decreasing steric demand of the alkyl substituent (isopropyl, ethyl and methyl) were obtained in four steps from the commercially available N-alkylaminoethanol compounds. The carbenes are hydrolytically sensitive, colorless oils that can be distilled without decomposition and show no sign of dimerization to the respective enetetramines, even after prolonged heating. Calculations at the B98/ 6-31G(d) level confirm that the dimerization of all three carbenes is thermodynamically unfavorable. To separate the steric and electronic stabilization of Wanzlick carbenes by N-alkyl substituents, the formation energies of R,H3 mono-alkyl enetetramines were used to derive electronic increments for the N-alkyl substituents. The computational data show that all alkyl substituents electronically stabilize Wanzlick carbenes vs. their dimerization products with increments ranging from 2.97 kcal mol-1 (N-methyl) to as high as 6.28 kcal mol-1 (N-tert-butyl). For combinations of N-methyl, N-ethyl and N-isopropyl substituents, the increments are additive and the dimerization energies were found to be free of noticeably steric effects. Significant steric strain was found for all tBu-substituted carbenes with strain energies of the dimerization products ranging from 6.92 kcal mol-1 [formation of (E)-Me2tBu2-enetetramine] to 24.23 kcal mol-1 (formation of tBu4 enetetramine). The tert-butyl substituent thus assumes a unique position by strongly stabilizing the carbenes electronically as well as sterically. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Amino pyrimidine compound and preparation method and application thereof

The invention relates to an amino pyrimidine compound and a preparation method and application thereof. The amino pyrimidine compound has a structure as shown in a formula I. The formula is shown in the description. The compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The invention further relates to a medicine composition comprising the compound, a preparation methodand application thereof in preparation of anti-tumor medicines.