899808-40-3

Upstream product

• 899808-39-0 4-iodomethyl-2-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 143-33-9 sodium cyanide 
• 256488-46-7 2-hydroxymethyl-4-phenyl-5-trifluoromethylthiophene 
• 100-66-3 methoxybenzene 
• 128100-35-6 5-(4-methoxyphenyl)pyrrolidin-2-one 
• 207989-87-5 5-(4-hydroxy-phenyl)-pyrrolidin-2-one 
• 899808-35-6 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 899808-30-1 2-oxo-5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 899808-36-7 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 
• 899808-37-8 4-hydroxymethyl-2-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 899808-29-8 2-oxo-5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 899808-31-2 2-oxo-5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-3-carboxylic acid ethyl ester 
• 899808-33-4 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-3-carboxylic acid ethyl ester 
• 899808-28-7 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one 

Downstream Products

• 899808-41-4 4-carboxymethyl-2-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

A series of 2-aryl(pyrrolidin-4-yl)acetic acids were synthesized and their biological activities were evaluated as agonists of S1P receptors. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to