899808-36-7Relevant articles and documents
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors
Yan, Lin,Budhu, Richard,Huo, Pei,Lynch, Christopher L.,Hale, Jeffrey J.,Mills, Sander G.,Hajdu, Richard,Keohane, Carol A.,Rosenbach, Mark J.,Milligan, James A.,Shei, Gan-Ju,Chrebet, Gary,Bergstrom, James,Card, Deborah,Mandala, Suzanne M.
, p. 3564 - 3568 (2007/10/03)
A series of 2-aryl(pyrrolidin-4-yl)acetic acids were synthesized and their biological activities were evaluated as agonists of S1P receptors. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to