90151-04-5

Usage

Uses

Used in Food Industry:
Benzaldehyde, 4-hydroxy-2-nitrois used as a flavoring agent in the food industry for its sweet, almond-like taste and strong aromatic properties. It helps enhance the flavor and aroma of various food products, contributing to a more enjoyable and appealing sensory experience for consumers.
Used in Perfume Industry:
In the perfume industry, Benzaldehyde, 4-hydroxy-2-nitrois utilized as a key ingredient in the formulation of fragrances. Its strong aromatic properties and unique scent profile make it an essential component in creating complex and long-lasting perfumes.
Used in Dye Industry:
Benzaldehyde, 4-hydroxy-2-nitrois employed in the dye industry for the production of various dyes. Its chemical properties allow it to be used as a precursor or intermediate in the synthesis of different types of dyes, contributing to the development of a wide range of colorants for various applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzaldehyde, 4-hydroxy-2-nitrois used in the synthesis of various drugs and pharmaceutical compounds. Its unique chemical structure makes it a valuable building block in the development of new medications and therapeutic agents.

Upstream product

• 67-66-3 chloroform 
• 554-84-7 meta-nitrophenol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 3899-90-9 3-nitrophenyl 4-methylbenzenesulfonate 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 62622-60-0 acetic acid-(4-methyl-3-nitro-phenyl ester) 
• 90792-80-6 α,α-Dibrom-2-nitro-4-acetoxy-toluol 

Downstream Products

• 105728-18-5 4-(3-nitro-4-formylphenyl)oxybutanoic acid 
• 105728-21-0 N-Cyclohexyl-4-(4-formyl-3-nitro-phenoxy)-N-methyl-butyramide 
• 94192-58-2 {2-Amino-4-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-benzylamino}-acetic acid ethyl ester 
• 94219-46-2 N-cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-8-yl)oxybutyramide 
• 1071155-71-9 {4-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester 
• 58662-54-7 5-benzyloxy-2-nitrobenzaldehyde 
• 92163-84-3 4-benzyloxy-2-nitrobenzaldehyde 
• 1224727-65-4 C₁₁H₁₁NO₆ 
• 148579-93-5 (2S,3R,4S,5S,6S)-2-(4-formyl-2-nitrophenoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 148579-94-6 (25,3R,45,55,65)-2-(4-(hydroxymethyl)-2-nitrophenoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 

Relevant academic research and scientific papers

TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE

The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

The novel usage of thiourea nitrate in aryl nitration

Thiourea nitrate (TN) was easily prepared from thiourea and nitric acid to explore its use as a new nitration reagent. Nitrations of various aromatic compounds utilizing TN in concentrated sulfuric acid were studied. TN could convert aromatic compounds to the corresponding nitrated derivatives with various abnormal yields under mild conditions. The results suggested that the reaction mechanism might be different from those of traditional nitration reagents.

BIOSYNTHETICALLY GENERATED PYRROLINE-CARBOXY-LYSINE AND SITE SPECIFIC PROTEIN MODIFICATIONS VIA CHEMICAL DERIVATIZATION OF PYRROLINE-CARBOXY-LYSINE AND PYRROLYSINE RESIDUES

Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein.

Nitric acid in the presence of P2O5 supported on silica gel - A useful reagent for nitration of aromatic compounds under solvent-free conditions

A variety of aromatic compounds are nitrated to parent nitro aromatic compounds under solvent-free conditions using 65% nitric acid in the presence of P2O5 supported on silica gel is described. This methodology is useful for nitration of activated and deactivated aromatic rings.

A fast and mild method for nitration of aromatic rings

The use of benzyltriphenylphosphonium nitrate (PhCH2Ph 3P+NO3-) (BTPPN) as a useful reagent for nitration aromatic compounds in the presence of methanesulfonic anhydride under solvent-free conditions is described. This methodology is useful for nitration of activated aromatic rings.

Vicarious nucleophilic substitution of hydrogen in nitrophenyl toluenesulfonates

Toluenesulfonates of nitrophenols react with carbanions possessing leaving groups giving products of the vicarious nucleophilic substitution of hydrogen. The yields and orientation depend on the reaction conditions and the structure of the reagents. The products obtained can be easily hydrolyxed to the corresponding phenols or - in certain cases - to hydroxynitrobenzaldehydes.

Gas/Solid Reactions with Nitrogen Dioxide

Numerous gas/solid reactions of nitrogen dioxide with organic substrates are investigated preparatively and mechanistically.Gaseous NO2 reacts with crystalline stable free radicals (nitroxyls 1, verdazyl 6) by electron transfer.The nitrite ions formed are irreversibly oxidized by NO2 via oxygen atom transfer.Solid cation nitrates are formed quantitatively.Thione bonds of thiohydantoins 8 are transformed to carbonyl bonds with formation of sulfur and NO presumably via nitrites as intermediates.Hydantoin 13 oxygenates at its free 5-methylene group via C-H abstraction and nitrite or it undergoes N-1 nitration via N-H abstraction depending on the conditions.Both reactions proceed quantitatively. 1,3-Oxazolidin-2-one (15) gives N-nitration and N-nitrosation with the NO produced.Nonenolized crystalline barbituric acids 17 are quantitatively nitrated (C-N bond formation with radicals) at their methylene groups. 4-Hydroxybenzaldehyde (19) and vanilline (22) give quantitative aromatic nitration (C-N bond formation with arenes) without melting.All possible regioisomers are formed.Solid 9-methylanthracene (26) gives a quantitative yield of its 10-nitro derivative 27.Crystalline anthracene (28) and gaseous NO2 yield 3 primary products 29 (cis; trans) and the new dimeric product 30 as well as the stable secondary products 31 and 32.The gas/solid tetranitration of tetraphenylethylene (33) is severely hindered by the water of reaction.However, a 95percent yield of pure tetrakis(p-nitrophenyl)ethylene is obtained if the drying agent MgSO4*2H2O is admixed and the product 34 extracted.The gas/solid procedures avoid solvents and fuming nitric acid.They give pure products without necessity for recrystallization in most cases and they avoid wastes.Atomic force microscopy (AFM) measurements on prominent faces of single crystals of 1a, 11a, 28, and 33 reveal phase rebuildings with well-directed long-range molecular transport.Nanoliquids were only present on (110) of 28.The characteristic AFM features are correlated with known X-ray crystal structure data and compared with previous results.The shape of the features depends on the molecular packing in the crystal bulk and on the molecular shapes.Molecular interpretations of the AFM features are given.