90155-46-7

Usage

Physical State

Clear liquid

Odor

Strong ammonia-like

Classification

Skin and eye irritant

Usage

Catalyst in organic synthesis

Applications

Manufacture of dyes, pharmaceuticals, and other organic compounds

Safety Precautions

Handle with care due to potential health hazards

Safety Measures

Proper safety precautions should be taken when working with it

Upstream product

• 7647-01-0 hydrogenchloride 
• 3190-01-0 racem-N,N'-dibenzylidene-bibenzyl-α,α'-diyldiamine 
• 612-00-0 1,1'-ethylidenebis-benzene 
• 52460-99-8 amino-diphenyl-acetonitrile 
• 119-61-9 benzophenone 
• 38093-52-6 acetylamino-diphenyl-acetonitrile 

Downstream Products

• 43171-49-9 (2-chlorophenyl)(4'-chlorophenyl)methanol 
• 112717-66-5 2,4,4-triphenylimidazoline 
• 1374823-93-4 C₃₀H₃₉N₃O₂S 
• 155320-77-7 (1R, 2S)-2-methoxycyclohexanol 
• 174390-40-0 (1S,2R)-2-methoxycyclohexanol 
• 642-04-6 2,3,5,6-tetraphenylpyrazine 

Relevant academic research and scientific papers

Electrophotocatalytic diamination of vicinal C-H bonds

The conversion of unactivated carbon-hydrogen (C-H) bonds to carbon-nitrogen (C-N) bonds is a highly valued transformation. Existing strategies typically accomplish such reactions at only a single C-H site because the first derivatization diminishes the reactivity of surrounding C-H bonds. Here, we show that alkylated arenes can undergo vicinal C-H diamination reactions to form 1, 2-diamine derivatives through an electrophotocatalytic strategy, using acetonitrile as both solvent and nitrogen source. The reaction is catalyzed by a trisaminocyclopropenium (TAC) ion, which undergoes anodic oxidation to furnish a stable radical dication while the cathodic reaction reduces protons to molecular hydrogen. Irradiation of the TAC radical dication (wavelength of maximum absorption of 450 to 550 nanometers) with a white-light compact fluorescent light generates a strongly oxidizing photoexcited intermediate. Depending on the electrolyte used, either 3, 4- dihydroimidazole or aziridine products are obtained.

NOVEL RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND USING SAME AS CATALYST

The present invention provides: a novel ruthenium complex which has excellent catalytic activity with respect to reactivity in the reduction of a multiple bond, in particular, in the asymmetric reduction of a carbonyl compound, enantioselectivity, etc.; a catalyst which comprises the ruthenium complex; and a process for producing optically active compound, in particular, an optically active alcohol compound, using the catalyst. The ruthenium complex has a ruthenacyclic structure. The catalyst is a catalyst for asymmetric reduction which comprises the ruthenium complex.

Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists

Novel imidazoline derivatives were discovered to be potent neuropeptide Y Y5 receptor antagonists. High-throughput screening of Merck sample collections against the human Y5 receptor resulted in the identification of 2,4,4-triphenylimidazoline (1), which had an IC50 of 54 nM. Subsequent optimization led to the identification of several potent derivatives.

ACYCLIC ETHYLENEDIAMINE DERIVATIVES

The present invention relates to novel acyclic ethylenediamine derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula STR1 wherein R 1, R 2, R 3, R 4, R. sup.5 and R 6 are defined as in the specification.

2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same

Compounds of the formula STR1 in which R1 and R2 independently of one another are substituted or unsubstituted aryl or hetero-aryl groups, R3 is hydrogen or lower alkyl and R4 is a substituted or unsubstituted a