A new efficient synthesis of ω-aminoalkylidene-1,1-bisphosphonate tetraethylesters

Article abstract of DOI:10.1080/10426509808036988

Bisphosphonates are interesting therapeutic agents in the management of bone diseases and since several years our laboratory has been developing the chemistry of 1,1-bisphosphonates. This paper describes an original synthesis of two aminoalkylidenebisphosphonates by first preparing the intermediate hydroxyalkylidenebisphosphonates which are transformed into amines via the azides.

Full text of DOI:10.1080/10426509808036988

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Phosphorus, Sulfur, and Silicon and the
Related Elements
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A NEW EFFICIENT SYNTHESIS OF ω-
AMINOALKYLIDENE-1,1-BISPHOSPHONATE
TETRAETHYLESTERS
Jean-Philippe Gourves a , Hélène Couthon a & Georges Sturtz a
a Laboratoire de Chimie Hetero-Organique, Université de Brest, 6
avenue Le Gorgeu, BP 809-29285, BREST, France
Published online: 24 Sep 2006.
To cite this article: Jean-Philippe Gourves , Hélène Couthon & Georges Sturtz (1998) A NEW EFFICIENT
SYNTHESIS OF ω-AMINOALKYLIDENE-1,1-BISPHOSPHONATE TETRAETHYLESTERS, Phosphorus, Sulfur, and
Silicon and the Related Elements, 132:1, 219-229, DOI: 10.1080/10426509808036988
To link to this article: http://dx.doi.org/10.1080/10426509808036988
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