90481-77-9

Basic information

• Product Name: 3-Bromo-N-(p-toluenesulfonyl)indole
• Synonyms: 3-Bromo-N-(p-toluenesulfonyl)indole;3-Bromo-1-(p-toluenesulfonyl)indole;1H-Indole, 3-bromo-1-[(4-methylphenyl)sulfonyl]-;3-BroMo-1-tosyl-1H-indole;3-Bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole
• CAS NO: 90481-77-9
• Molecular Formula: C₁₅H₁₂BrNO₂S
• Molecular Weight: 350.23
• Product Categories: Indole;Organohalides
• Mol File: 90481-77-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 502.8 °C at 760 mmHg
• Flash Point: 257.9 °C
• Appearance: /
• Density: 1.51 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Bromo-N-(p-toluenesulfonyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-N-(p-toluenesulfonyl)indole(90481-77-9)
• EPA Substance Registry System: 3-Bromo-N-(p-toluenesulfonyl)indole(90481-77-9)

Safety Data

• Hazardous Substances Data: 90481-77-9(Hazardous Substances Data)

Usage

General Description

3-Bromo-N-(p-toluenesulfonyl)indole is a chemical compound derived from Indole, which encompasses a structure of benzopyrrole with a bromine and a nitrogen atom. It is utilized mainly in academic and industrial research, which includes organic chemical syntheses and the production of various pharmaceuticals. Its name follows the International Union of Pure and Applied Chemistry (IUPAC) nomenclature, which identifies the elements and functional groups present in the molecule. Safety measures should be adhered to when handling this chemical due to the potential health hazards it may cause.

Upstream product

• 31271-90-6 1-(p-toluenesulfonyl)-1H-indole 
• 120-72-9 indole 
• 98-59-9 p-toluenesulfonyl chloride 
• 1484-27-1 3-bromoindole 
• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 
• 370090-66-7 1-tosyl-1H-indole-3-carboxylic acid 

Downstream Products

• 887339-08-4 1-tosyl-3-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)-1H-indole 
• 887338-43-4 3-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-1H-indole 
• 1352714-47-6 2-(3-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)-1H-indol-1-yl)acetic acid 
• 1352714-46-5 C₄₆H₄₇NO₇ 
• 314083-22-2 3-(1-piperazyl)-1-tosylindole 
• 333303-43-8 4-allyl-3-(3-methyl-buta-1,3-dienyl)-1-(toluene-4-sulfonyl)-1H-indole 
• 333303-42-7 4-[4-allyl-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-but-3-en-2-one 
• 333303-41-6 4-allyl-3-bromo-1-(toluene-4-sulfonyl)-1H-indole 
• 333303-40-5 3-bromo-4-N-p-toluenesulfonylindole 
• 151451-40-0 ethyl (E)-3-[1-(4-toluenesulfonyl)indole-3-yl]propenoate 

Relevant articles and documents

Syntheses of Heterocycle-2,3-Fused Indoline and Azaindoline -Derivatives

We describe a practical method for synthesizing heterocycle-2,3-fused indoline or azaindoline derivatives through haloetherification and cyclization. We applied this method in syntheses of six- to eight-membered heterocycle-2,3-fused indoline and azaindoline derivatives. These derivatives, which contain sp 3 -hybridized carbons, might be useful as new scaffolds in medicinal chemistry.

Cooperativity within the catalyst: alkoxyamide as a catalyst for bromocyclization and bromination of (hetero)aromatics

Alkoxyamide has been reported as a catalyst for the activation ofN-bromosuccinimide to perform bromocyclization and bromination of a wide range of substrates in a lipophilic solvent, where adequate suppression of the background reactions was observed. The key feature of the active site is the alkoxy group attached to the sulfonamide moiety, which facilitates the acceptance as well as the delivery of bromonium species from the bromine source to the substrates.

Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol

Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.