90761-31-2

Usage

InChI:InChI=1/C13H14Cl2O3/c14-9-3-1-8(12(15)5-9)2-4-11-6-10(16)7-13(17)18-11/h1,3,5,10-11,16H,2,4,6-7H2

Upstream product

• 129752-76-7 (3aR,6R,7aR)-6-Methoxy-4-methylene-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one 
• 6752-48-3 (2S,4aS,6R,8R,8aR)-6-Methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-ol 
• 129752-85-8 (2S,4S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-2-methoxy-3,4-dihydro-2H-pyran-4-ol 
• 311-28-4 tetra-(n-butyl)ammonium iodide 
• 90691-50-2 (4R,6R)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-tetrahydro-pyran-2,4-diol 
• 96720-15-9 6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one 
• 141263-62-9 1-Cyano-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-2,4-hexanediol 
• 96720-09-1 ethyl 6-<(tert-butyldiphenylsilyl)oxy>-5(S,E)-hydroxy-2-hexenoate 
• 96720-12-6 (3R,5S)-6-Bromo-5-(tert-butyl-diphenyl-silanyloxy)-3-methoxymethoxy-hexanoic acid ethyl ester 
• 101910-04-7 (Z)-(3R,5R)-7-(2,4-Dichloro-phenyl)-1-phenylsulfanyl-hept-1-ene-3,5-diol 
• 101910-01-4 (3aR,5R,6aR)-5-[2-(2,4-Dichloro-phenyl)-ethyl]-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 101910-00-3 (3aR,5S,6aR)-5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 2492-23-1 <(2,4-dichlorophenyl)-methyl>triphenylphosphonium chloride 
• 4613-68-7 O¹,O²-isopropylidene-α-D-erythro-3-deoxy-pentodiald-1,4-ose 

Downstream Products

• 111505-88-5 6-<2-(2,4-dichlorophenyl)ethyl>-5,6-dihydro-2H-pyran-2-one 
• 111505-91-0 (4S,6R)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-phenyl-tetrahydro-pyran-2-one 
• 111505-91-0 (4S,6S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-phenyl-tetrahydro-pyran-2-one 
• 111505-96-5 C₂₁H₁₈Cl₂F₃NO₄ 
• 111505-93-2 4-{(2S,4S)-2-[2-(2,4-Dichloro-phenyl)-ethyl]-6-oxo-tetrahydro-pyran-4-yl}-benzoic acid methyl ester 
• 111505-92-1 (4S,6S)-4-Biphenyl-4-yl-6-[2-(2,4-dichloro-phenyl)-ethyl]-tetrahydro-pyran-2-one 
• 111505-99-8 (4S,6S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-(2-methoxy-phenyl)-tetrahydro-pyran-2-one 
• 111505-98-7 (4S,6S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-(2-hydroxymethyl-phenyl)-tetrahydro-pyran-2-one 
• 111505-94-3 (4S,6S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-(4-methoxy-phenyl)-tetrahydro-pyran-2-one 
• 111505-97-6 (4S,6S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-(3-methoxy-phenyl)-tetrahydro-pyran-2-one 
• 111506-00-4 (4S,6S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-(3-iodo-pyrazol-1-yl)-tetrahydro-pyran-2-one 
• 111505-95-4 (4S,6S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-(4-hydroxy-phenyl)-tetrahydro-pyran-2-one 
• 111506-01-5 (4S,6S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-thiophen-3-yl-tetrahydro-pyran-2-one 
• 111506-05-9 Z,E-7-(2,4-dichlorophenyl)-2,4-heptadienoic acid 

Relevant academic research and scientific papers

Synthesis of 7-(2,4-dichlorophenyl)-D-erythro-3-hydroxy-5-heptanolide, 6-(2,4-dichlorophenyl)-D-erythro-2,4-dihydroxyhexane-1-sulfonic acid, and 6-(2,4-dichlorophenyl)-D-erythro-2,4-dihydroxyhexylphosphonic acid

6-(2,4-Dichlorophenyl)-D-erythro-1,2,4-hexanetriol, synthesised from D-glucose, was partially silylated, then reacted with 2-methoxypropene to afford 1-O-tert-butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol (17).

A new strategy for the synthesis of mevinic acid analogues

The reaction of the allylic carbonate 2 with organocopper derivatives is the key step of a new strategy for the synthesis of mevinic acid analogues. (Chemical Equation Presented).

Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein

This invention relates to a novel process for the preparation of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which contain a 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety, such as compactin and mevinolin, by utilizing an alkyl

AN EXPEDITIOUS CHIRAL ROUTE TO ANALOGS OF MEVINOLIN AND COMPACTIN

A new and novel approach to the preparation of optically active analogs of mevinolin and compactin, in which the β-hydroxy-δ-lactone moiety is derived from D-glucose, is described.

PREPARATION OF ETHYL 5(S),6-EPOXY-3(R)-(METHOXYMETHOXY)HEXANOATE: A KEY CHIRAL INTERMEDIATE FOR MEVINOLIN AND COMPACTIN.

The synthesis of Ethyl 5(S),6-Epoxy-3(R)-(methoxymethoxy)hexanoate, a key chiral synthon for the β-hydroxy-δ-lactone portion of Mevinolin and Compactin, via a regiospecific ring opening of a tetrahydrofuran derivative by dimethyboron bromide, is described.

PROCESS FOR PREPARING INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE VIA A CHIRAL SYNTHON

Totally synthetic analogs of the known inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, compactin and mevinolin, are prepared from a chiral synthon derived from D-glucose which has the same chirality as the natural products.