908303-06-0

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 108-59-8 malonic acid dimethyl ester 
• 104-55-2 3-phenyl-propenal 
• 104-53-0 3-phenyl-propionaldehyde 
• 104-54-1 3-Phenylpropenol 

Downstream Products

• 1332624-57-3 (S)-methyl 6-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-5-carboxylate 
• 222050-57-9 (R)-2-methoxycarbonyl-3-phenylpentane-1,5-dioic acid 1,5-dimethyl ester 
• 1256944-52-1 (2R,3S,12bR)-methyl 9-methoxy-4-oxo-2-phenyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-3-carboxylate 
• 1256944-49-6 (2R,3S,12bR)-methyl 9-bromo-4-oxo-2-phenyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-3-carboxylate 
• 1133909-62-2 (2R,3S,12bR)-methyl 1,2,3,4,6,7,12,12b-octahydro-4-oxo-2-phenylindolo[2,3-a]quinolizine-3-carboxylate 
• 1247042-21-2 C₂₄H₂₈O₇ 

Relevant academic research and scientific papers

A Recyclable Chiral 2-(Triphenylmethyl)pyrrolidine Organocatalyst Anchored to [60]Fullerene

Hybridization of a chiral 3-hydroxy-2-trityl-pyrrolidine deriving from (R)-pyrrolidinol with [60]fullerene via click chemistry provides a highly efficient supported enantioselective organocatalyst, which was successfully exploited in a Michael addition of

synthetic method of β-substituted optical active carbonyl compounds

The present invention relates to a method for synthesizing compounds such as an andalpha;, andbeta;-substituted optically active carbonyl compound represented by the chemical formula 1-1 and a andbeta;-substituted optically active carbonyl compound represented by the chemical formula 4-1 in a significant manner. The optically active carbonyl compounds can be synthesized through a continuous series of an oxidation reaction, a Michael addition reaction, and a selective andalpha;-oxyamination reaction while using allylic alcohol as a starting material.COPYRIGHT KIPO 2018

Distribution of Catalytic Species as an Indicator to Overcome Reproducibility Problems

Irreproducibility is a common issue in catalysis. The ordinary way to minimize it is by ensuring enhanced control over the factors that affect the reaction. When control is insufficient, some parameters can be used as indicators of the reaction performanc

Hollow structural effect of microporous organocatalytic polymers with pyrrolidines: Dramatic enhancement of catalytic performance

Hollow and microporous organic polymers bearing pyrrolidines (H-MOP-P) were prepared by template synthesis and post-synthetic modification. H-MOP-P showed enhanced organocatalytic performance, compared to nonhollow microporous catalysts.

Exploration of Structural Frameworks for Reactive and Enantioselective Peptide Catalysts by Library Screenings

By screening large-scale N-terminal l-prolyl peptide libraries, we explored efficient catalysts for asymmetric Michael addition of a malonate to an enal. The catalytically active peptides obtained by the screening could be categorized into two groups base

Heterogeneous J?rgensen–Hayashi catalyst for asymmetric Michael addition of malonates to α,β-enals. Cooperative effect with Ca(OTf)2

Heterogeneous chiral J?rgensen–Hayashi catalyst promotes enantioselective Michael addition of malonates at cinnamic aldehydes. In combination with Ca(OTf)2, it provides high yields (up to 78%) and excellent enantiomeric excesses (up to 99%) of

Enantioselective β-Alkylation of Aldehydes through an Organocatalyzed C-C Bond-Scission Reaction

A novel organocatalyzed C-C bond-scission reaction of saturated aldehydes containing a suitable leaving group at the β-position was used for the in situ formation of iminium intermediates, which were then captured by nucleophiles to achieve a direct enantioselective β-alkylation of aldehydes. Within short reaction times, the corresponding β-alkylated aldehyde products were obtained in high yields (48-87%) and with excellent enantioselectivities (84-98%).

Histidine-containing peptide catalysts developed by a facile library screening method

Although peptide catalysts have a high potential for the use as organocatalysts, the optimization of peptide sequences is laborious and time-consuming. To address this issue, a facile screening method for finding efficient aminocatalysts from a peptide li

α, β- substituted carbonyl compounds, optical active heterocyclic compounds derived from the same, and synthetic method thereof

The present invention relates to an α, β- substituted optically active carbonyl compound represented by the chemical formula 1-1; a 3,4,5- substituted optically active piperidine compound; and a heterocyclic compound such as a lactone and pyrrolidone. Various heterocyclic compounds manifest physiological activities such as antioxidant effects.

synthetic method of β-substituted optical active carbonyl compounds

The present invention provides a method for synthesizing an andalpha;,andbeta;-substituted optically active carbonyl compound represented by chemical formula 1-1 and a andbeta;-substituted optically active carbonyl compound represented by chemical formula