91-76-9

Basic information

• Product Name: 2,4-Diamino-6-phenyl-1,3,5-triazine
• Synonyms: 2,4-diamino-6-phenyl-s-triazin;2-Phenyl-4,6-diamino-1,3,5-triazine;2-Phenyl-4,6-diamino-s-triazine;3,5-Triazine-2,4-diamine,6-phenyl-1;4,6-Diamino-2-phenyl-s-triazine;5-triazine,2,4-diamino-6-phenyl-3;5-triazine-2,4-diamine,6-phenyl-3;6-Phenyl-1,3,5-triazine-2,4-diyldiamine
• CAS NO: 91-76-9
• Molecular Formula: C9H9N5
• Molecular Weight: 187.2
• EINECS: 202-095-6
• Product Categories: Intermediates of Dyes and Pigments;Heterocyclic Compounds;Benzenes;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Triazines
• Mol File: 91-76-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 219-221 °C(lit.)
• Boiling Point: 311.95°C (rough estimate)
• Flash Point: 285.8 °C
• Appearance: white crystalline powder
• Density: 1.4
• Vapor Pressure: 5.71E-10mmHg at 25°C
• Refractive Index: 1.6900 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 0.3g/l
• PKA: 4.22±0.10(Predicted)
• Water Solubility: 320mg/L at 25℃
• Merck: 14,1089
• BRN: 153223
• CAS DataBase Reference: 2,4-Diamino-6-phenyl-1,3,5-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Diamino-6-phenyl-1,3,5-triazine(91-76-9)
• EPA Substance Registry System: 2,4-Diamino-6-phenyl-1,3,5-triazine(91-76-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-52/53
• Safety Statements: 61
• WGK Germany: 2
• RTECS: XY7000000
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 91-76-9(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Uses

In the manufacture of thermosetting resins, pesticides, pharmaceuticals and dyestuffs.

Preparation

Benzoguanamine closely resembles melamine in that reaction with formaldehyde gives methylol derivatives and then resinous condensates. Butylated benzoguanamine-formaldehyde resins have found some use in surface coatings. In a typical preparation, benzoguanamine (1 mole) is heated with formalin (3 mole formaldehyde) at pH 8.3 and 70-80°C until the guanamine has dissolved. n-Butanol (9 mole) and a small amount of hydrochloric acid are added and the azeotrope distilled off until removal of water is complete. Like their melamine counterparts, butylated benzoguanamine-formaldehyde resins are most commonly used in admixture with alkyd resins. The resulting coatings are very similar to those based on melamine but they show improved resistance to alkalis.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C9H9N5/c10-8-12-7(13-9(11)14-8)6-4-2-1-3-5-6/h1-5H,(H4,10,11,12,13,14)

Upstream product

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Downstream Products

• 712-60-7 2,6-difluoro-4-phenyl-s-triazine 

Relevant articles and documents

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2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof

The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.

Novel benzoguanamine production method

The invention discloses a novel benzoguanamine production method. The method comprises the following steps that 1, a certain amount of alkanol is added into a reaction vessel to serve as a solvent, benzonitrile and dicyandiamide are added, and on the condition that an inorganic base serves as a catalyst, a complete reaction is conducted; 2, reactant is cooled to be below 40 DEG C, suction filtration is conducted, and solid-liquid separation is achieved; 3, all solid substances obtained through suction filtration are transferred into the vessel, pure water of which the volume is 1-3 times that of the solid substances is added, heating and constant-temperature evaporation are conduced for 1 h to 3 h, and suction filtration is conducted when the solid substances are hot; 4, solid substances obtained through suction filtration in the third step are added into hot water of which the volume is 1-3 times that of the obtained solid substances to be washed with water for 10 min to 30 min, and suction filtration is conducted again to obtain solid substances; 5, the solid substances obtained through suction filtration in the fourth step are dried and crushed, and the competitive benzoguanamine product is obtained. According to the production method, the conversion rate of the production raw materials is high, the purity of the obtained product is high, unreacted raw materials in the benzoguanamine production process can be effectively recycled, and therefore types and COD of organic matter in wastewater after reaction are obviously reduced.