911218-03-6

Basic information

• Product Name: (1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL
• Synonyms: (1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL;(S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL;(αS)-2-Chloro-4-fluoro-α-Methyl-benzeneMethanol
• CAS NO: 911218-03-6
• Molecular Formula: C8H8ClFO
• Molecular Weight: 174.6
• Mol File: 911218-03-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL(911218-03-6)
• EPA Substance Registry System: (1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL(911218-03-6)

Safety Data

• Hazardous Substances Data: 911218-03-6(Hazardous Substances Data)

Usage

Description

(1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL, also known as (αS)-2-chloro-4-fluoro-α-methyl-benzenemethanol, is a synthetic intermediate with a unique molecular structure featuring a chiral center and functional groups that make it a versatile compound in various chemical reactions and applications.

Uses

Used in Pharmaceutical Industry:
(1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL is used as a synthetic intermediate for the development of pharmaceutical compounds, particularly in the synthesis of chiral drugs. Its unique structure allows for the creation of enantiomerically pure compounds, which is crucial for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Chemical Synthesis:
(1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL is used as a building block in the synthesis of various organic compounds, including agrochemicals, fragrances, and specialty chemicals. Its reactivity and functional groups enable it to participate in a wide range of chemical reactions, making it a valuable component in the synthesis of complex molecules.
Used in Environmentally Friendly Synthesis:
(1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL can be prepared using environmentally friendly reagents such as baker's yeast (BY), which promotes green chemistry practices. This eco-friendly approach to synthesis reduces the environmental impact of chemical production and contributes to sustainable chemical processes.

Upstream product

• 75-16-1 methylmagnesium bromide 
• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 700-35-6 2'-chloro-4'-fluoroacetophenone 
• 2252-51-9 2-choro-4-fluorobenzoic acid 

Relevant articles and documents

ATF6 MODULATORS AND USES THEREOF

Compounds (I) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer.

VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS

FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.

Towards a Large-Scale Asymmetric Reduction Process with Isolated Enzymes: Expression of an (S)-Alcohol Dehydrogenase in E. coli and Studies on the Synthetic Potential of this Biocatalyst

An NAD-dependent and widely applicable (S)-alcohol dehydrogenase is isolated and described as a novel enzyme. It is expressed in an E. coli strain with a high production potential. The application of this enzyme in asymmetric biocatalytic reduction is presented as well. This enzyme shows a broad substrate range comprising aliphatic and aromatic ketones as well as β-keto esters. The synthetic application of this new (S)-alcohol dehydrogenase led to optically active alcohols in high conversion rates accompanied by enantioselectivities of up to > 99% ee. Compared to the wild-type enzyme significant advantages are observed besides the improved availability, such as a high enantioselectivity independent of the reaction time. Furthermore, the alcohol dehydrogenase was cloned and successfully overexpressed in E. coli resulting in a biocatalyst with a potential to be available on technical scale in the future. The development of a large-scale available and widely applicable (S)-alcohol dehydrogenase is one prerequisite to use isolated enzymes for asymmetric reduction processes as a valuable tool.