91245-57-7Relevant articles and documents
Unusual ambiphilic carbenoid equivalent in amide cyclopropanation
Lin, Kuo-Wei,Yan, Shiuan,Hsieh, I.-Lin,Yan, Tu-Hsin
, p. 2265 - 2267 (2006)
The titanium-methylene complexes derived from the TiCl4-Mg- CH2Cl2 system serve as a novel class of ambiphilic carbenoid equivalents, which not only efficiently effect cyclopropanations of a variety amides but also exhibit
N-Alkyl-N-Cyclopropylanilines as Mechanistic Probes in the Nitrosation of N,N-Dialkyl Aromatic Amines
Loeppky, Richard N.,Elomari, Saleh
, p. 96 - 103 (2007/10/03)
A group of N-cyclopropyl-N-alkylanilines has been synthesized, and their reaction with nitrous acid in aqueous acetic acid at 0°C was examined. All compounds reacted rapidly to produce the corresponding N-alkyl-N-nitrosoaniline by specific cleavage of the cyclopropyl group from the nitrogen. The transformations were unaffected by the nature of the alkyl substituent (Me, Et, iPr, Bn). The reaction of 4-chloro-N-2-phenylcyclopropyl-N-methylaniline with nitrous acid gave 4-chloro-N-methyl-N-nitrosoaniline (76%), cinnamaldehyde (55%), 3-phenyl-5-hydroxyisoxazoline (26%), and 5-(N-4-chlorophenylmethylamino)-3-phenylisoxazoline (8%). Both the selective cleavage of the cyclopropyl group from the aromatic amine nitrogen and nature of the products derived from the cyclopropane ring support a mechanism involving the formation of an amine radical cation. This step is followed by rapid cyclopropyl ring opening to produce an iminium ion with a C-centered radical which either combines with NO or is oxidized.