914299-22-2 Usage
Uses
Used in Pharmaceutical Industry:
2-(3-METHOXYCARBONYL-2-METHYL-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a potential building block for the synthesis of pharmaceutical compounds due to its unique structural features and reactivity.
Used in Chemical Industry:
2-(3-METHOXYCARBONYL-2-METHYL-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a potential candidate for exhibiting biological activities and for the development of new chemical processes or reactions.
Further research and testing may be required to fully understand the chemical properties and potential uses of 2-(3-METHOXYCARBONYL-2-METHYL-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 914299-22-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,2,9 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 914299-22:
(8*9)+(7*1)+(6*4)+(5*2)+(4*9)+(3*9)+(2*2)+(1*2)=182
182 % 10 = 2
So 914299-22-2 is a valid CAS Registry Number.
914299-22-2Relevant academic research and scientific papers
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
Kung, Pei-Pei,Funk, Lee,Meng, Jerry,Collins, Michael,Zhou, Joe Zhongxiang,Catherine Johnson,Ekker, Anne,Wang, Jeff,Mehta, Pramod,Yin, Min-Jean,Rodgers, Caroline,Davies II, Jay F.,Bayman, Eileen,Smeal, Tod,Maegley, Karen A.,Gehring, Michael R.
supporting information; experimental part, p. 6273 - 6278 (2009/08/15)
Information from X-ray crystal structures were used to optimize the potency of a HTS hit in a Hsp90 competitive binding assay. A class of novel and potent small molecule Hsp90 inhibitors were thereby identified. Enantio-pure compounds 31 and 33 were potent in PGA-based competitive binding assay and inhibited proliferation of various human cancer cell lines in vitro, with IC50 values averaging 20 nM.
AMIDE RESORCINOL COMPOUNDS
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Page/Page column 41; 110, (2008/06/13)
The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.
