52570-33-9

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3-iodo-2-methylbenzoate is used as a building block for the synthesis of diverse biologically active compounds. It plays a crucial role in the development of new drugs and pharmaceuticals due to its unique chemical properties and reactivity.
Used in Agrochemical Industry:
In the agrochemical industry, methyl 3-iodo-2-methylbenzoate is utilized as a key intermediate in the synthesis of various agrochemicals, including pesticides and herbicides. Its unique structure and reactivity contribute to the development of effective and targeted agrochemical products.
Safety Precautions:
Methyl 3-iodo-2-methylbenzoate should be handled with care as it is toxic if ingested, inhaled, or comes in contact with the skin and eyes. Proper safety measures, such as wearing protective clothing and using appropriate containment systems, should be taken to minimize exposure and potential health risks.

Upstream product

• 67-56-1 methanol 
• 52107-91-2 3-iodo-2-methylbenzoic acid chloride 
• 133232-56-1 3-iodo-2-methylbenzoic acid 
• 52130-17-3 3-amino-2-methylbenzoic acid 

Downstream Products

• 312747-81-2 methyl 2-(bromomethyl)-3-iodobenzoate 
• 914299-19-7 C₁₁H₁₂IN 
• 914299-20-0 C₁₁H₁₄IN 
• 914299-95-9 methyl 2-methyl-3-pyrrolidin-2-ylbenzoate 
• 914299-21-1 C₁₆H₂₂INO₂ 
• 914299-22-2 C₁₈H₂₅NO₄ 
• 914299-23-3 methyl 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-2-methylbenzoate 
• 914299-24-4 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-2-methylbenzoic acid 
• 914299-25-5 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-2-methylbenzamide 

Relevant academic research and scientific papers

DIMERIC IMMUNO-MODULATORY COMPOUNDS AGAINST CEREBLON-BASED MECHANISMS

Disclosed are small molecules against cereblon to enhance effector T cell function. Methods of making these molecules and methods of using them to treat various disease states are also disclosed.

OXOINDOLINE DERIVATIVES AS PROTEIN FUNCTION MODULATORS

The present invention provides chimeric compounds of formula (II) that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, TNF-alpha activity, CKl-alpha activity and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions, such as cytokine-mediated diseases, disorders, and conditions, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, organ transplant rejection, and cancer, are provided.

ALPHA-CARBOLINE DERIVATIVES AND METHODS FOR PREPARATION THEREOF

To provide methods for preparing alpha-carboline derivatives in few steps, as well as conveniently and industrially advantageously. A method for preparation of a compound represented by Formula (II) or a salt thereof, comprising subjecting a compound represented by Formula (I) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base; a method for preparation of a compound represented by Formula (IX) or a salt thereof, comprising subjecting a compound represented by Formula (VII) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base, and subsequently to an aromatization reaction; and methods for preparation of compounds represented by Formulae (XV), (XVII), and (XIX) or a salt thereof, comprising subjecting respective compounds represented by Formulae (II) and (IX) or a salt thereof to a reaction for introducing a leaving group when necessary, and subsequently to a coupling reaction: wherein the symbols respectively represent the same meaning as defined in the present specification.

Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone

Information from X-ray crystal structures were used to optimize the potency of a HTS hit in a Hsp90 competitive binding assay. A class of novel and potent small molecule Hsp90 inhibitors were thereby identified. Enantio-pure compounds 31 and 33 were potent in PGA-based competitive binding assay and inhibited proliferation of various human cancer cell lines in vitro, with IC50 values averaging 20 nM.

CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF

The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure: Formula (I).

AMIDE RESORCINOL COMPOUNDS

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.