Enantiomer resolution of nefopam hydrochloride, a novel analgesic: A study by liquid chromatography and circular dichroism spectroscopy

DOI: 10.1111/j.2042-7158.1988.tb05148.x

Source and publish data:

Journal of Pharmacy and Pharmacology p. 48 - 50 (1988)

Update date:2022-08-28

Topics:

Authors:

Isaksson

Sandstrom

Eliaz Eliaz

Israely Israely

Agranat Agranat

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Article abstract of DOI:10.1111/j.2042-7158.1988.tb05148.x

Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low-pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported.

Full text of DOI:10.1111/j.2042-7158.1988.tb05148.x

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