91497-49-3

Upstream product

• 49653-17-0 ethyl 2-ethoxyglycolate 
• 98-86-2 acetophenone 
• 94402-76-3 Ethyl trans-2,3-Epoxy-4-oxo-4-phenylbutanoate 
• 924-44-7 glyoxylic acid ethyl ester 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 64805-08-9 ethyl glyoxylate hydrate 

Downstream Products

• 15121-89-8 ethyl 3-benzoyl acrylate 
• 146912-63-2 (S)-2-hydroxy-4-oxo-4-phenylbutanoic acid 
• 244277-48-3 ethyl (R)-(-)-2-hydroxy-4-oxo-4-phenylbutanoate 

Relevant academic research and scientific papers

Hydrogenation of ethyl esters of 4-phenyl- and (2-furyl)-substituted 2,4-dioxobutyric acids at palladium black

The hydrogenation of ethyl 4-R-2,4-dioxobutyrates (R = phenyl, 2-furyl) at 5% Pt/Al2O3 catalyst, modified with cinchonidine, and at palladium black was investigated. The former had low activity under the conditions we tested. The mai

Base- and metal-free decarboxylative aldol reaction of β-ketoacids with glyoxylate hydrates and glyoxal monohydrates in water

An environmentally benign decarboxylative aldol reaction of β-ketoacids with glyoxylate and glyoxal monohydrates in water is reported. The reaction proceeds smoothly without any base and metal catalysts, affording the corresponding β-hydroxy ketones in high yields. A preliminary mechanism study of this aldol transformation suggests a stepwise process involving the nucleophilic addition of β-ketoacids to glyoxylate hydrates and glyoxal monohydrates followed by a subsequent decarboxylation reaction.

Reductive ring-opening reaction of 2,3-epoxy-1,4-butanediones with SbCl3-Bu4NI in the presence of Na2S 2O3·5H2O

1,4-Disubstituted 2,3-epoxy-1,4-butanediones were converted to 1,4-disubstituted 2-hydroxy-1,4-butanediones with SbCl3-Bu 4NI in the presence of Na2S2O 3-5H2O. The ring opening of terminal epoxides can also be accomplished to afford the corresponding haloalcohol with SbCl3 and tetrabutylammonium halides, Bu4NX (X = Cl, Br, I) under the same reaction conditions. Copyright Taylor & Francis, Inc.

Bismuth triflate catalyzed Mukaiyama aldol reaction in an ionic liquid

We have developed an efficient, bismuth triflate catalyzed Mukaiyama aldol reaction. The reaction proceeds rapidly and affords the corresponding β-hydroxy carbonyl compound in moderate to very good yields (up to 92%). Wiley-VCH Verlag GmbH & Co. KGaA, 200