91544-03-5

Usage

Synthesis Reference(s)

Synthetic Communications, 17, p. 1831, 1987 DOI: 10.1080/00397918708077328

Upstream product

• 26947-41-1 3-cyanoisoquinoline 
• 50458-79-2 ethyl isoquinoline-3-carboxylate 
• 141-78-6 ethyl acetate 
• 917-64-6 methyl magnesium iodide 
• 917-54-4 methyllithium 
• 86520-97-0 3-Ethynyl-isoquinoline 
• 4504-27-2 1-azidopropan-2-one 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 114196-60-0 C₂₁H₂₀NOP 
• 27104-73-0 methyl isoquinoline-3-carboxylate 
• 75-16-1 methylmagnesium bromide 
• 111-34-2 -butyl vinyl ether 
• 185950-63-4 3-((trifluoromethylsulfonyl)oxy)isoquinoline 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 

Downstream Products

• 362057-59-8 (+/-)-3-(1-trityloxyethyl)isoquinoline 
• 362057-58-7 (+/-)-3-{1-[(tert-butyldiphenylsilyl)oxyethyl]}isoquinoline 
• 58794-05-1 (+/-)-1-(isoquinolin-3-yl)ethanol 
• 259251-58-6 2,6-bis(3-isoquinolyl)-4-(p-tolyl)pyridine 

Relevant academic research and scientific papers

Synthesis, photophysical and electrophosphorescent properties of fluorene-based platinum(II) complexes

A series of platinum(II) complexes bearing tridentate cyclometalated C^N^N (C^N^N=6-phenyl-2,2'-bipyridine and π-extended R-C^N^N=3-[6'-(naphthalen-2''- yl)pyridin-2'-yl]isoquinoline) ligands with fluorene units have been synthesised and their photophysic

Homochiral isoquinolines by lipase-catalysed resolution and their diastereoselective functionalisation

Kinetic resolution of racemic isoquinoline alcohols and acetates has been successfully accomplished using lipases as chiral catalysts. The diastereoselective functionalisation of the isoquinoline moiety through the addition of C-nucleophiles to O-protected alcohol 9a in the presence of phenyl chloroformate has been carried out and dihydroquinolyl alcohol derivatives with high diastereomeric excess have been prepared.

Syntheses of acetylquinolines and acetylisoquinolines via palladium-catalyzed coupling reactions

Acetylquinolines and acetylisoquinolines were obtained from the corresponding chloro-, bromo- or trifluoromethylsulfonyloxy-heteroaromatics via four different palladium-catalyzed coupling reactions: (i) Stille coupling with tri(n-butyl)-1-ethoxyvinylstannane; (ii) Negishi coupling with 1-ethoxyvinylzinc chloride; (iii) cross-coupling with tri(1-ethoxyvinyl)indium; (iv) Heck arylation of n-butyl vinyl ether.

Electrophilic activation of acetyl-substituted heteroaromatic compounds

The chemistry of acetyl-substituted pyridines, thiazoles, quinoline, isoquinolines, and pyrazine (1-9 and 28) has been studied. These heteroarenes (1-8) condense with benzene in good yields (74-96%) in the Bronsted superacid, CF3SO3H (triflic acid). In these acid-catalyzed hydroxyalkylation reactions, compounds 1-8 are significantly more reactive than acetophenone. It is proposed that compounds 1-8 readily form dicationic electrophiles in triflic acid.

Alpha-substituted pyrimidine-thioalkyl and alkylether compounds as inhibitors of viral reverse transcriptase

The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R 4 is selected from the group consisitng of --H or --NR 15 R 16 where R 15 is --H and R 16 is --H, C 1 -C 6 alkyl, NH 2 or R 15 and R 16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R 6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R 4 and R 6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase. STR1

Electrochemical and spectroscopic properties of cyclometallated and non- cyclometallated ruthenium(II) complexes containing sterically hindering ligands of the phenanthroline and terpyridine families

Two series of cyclometallated and noncyclometallated ruthenium(II) complexes incorporating mono- or disubstituted 1,10-phenanthroline- and 2,2':6',2''-terpyridine-type ligands have been synthesized and characterized. An X-ray crystal structure for one of the complexes, Ru(ttpy)(mapH)(Cl)(PF6), has been obtained (mapH = 2-p-anisyl-1,10- phenanthroline; ttpy = 4'-tolyl-2,2':6',2''-terpyridine). Distinct electrochemical and photophysical properties have been observed for the two series: a remarkable feature is the observation of relatively long-lived MLCT excited states (from 70 to 106 ns at room temperature in CH3CN) for three of the cyclometallated complexes. A discussion is given on the role of factors like sigma donation by the cyclometallating ligands, interligand steric hindrance and interligand π-π interactions that affect the electrochemical and spectroscopic properties.

Propenoic acid derivatives useful as fungicides

A fungicidal compound of formula (I): STR1 wherein A is hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, phenoxy, nitro or cyano; and one of R1 and R2 is optionally substituted isoquinoline while the other is hydrogen, C1-4 alkyl, C1-4 haloalkyl, halogen or cyano.

Fused azolium salts XVIII [1]. Synthesis and reactivity of a novel fused heteroaromatic system : [1,2,3]triazolo[1,5-b]isoquinolinium salts

Oxidative cyclization of 3-isoquinolyl ketone hydrazones afforded the novel tricyclic heteroaromatic [1,2,3]triazolo[1,5-b]isoquinolinium salts. The reactivity of the ring system towards nucleophiles proved to be regioselective. Secondary amines induced r

Nouvelle voie de synthese d'isoidindolones et d'isoquinoleines par condensation d'iminophosphoranes avec l'ortho-phthalaldehyde: reactions, mecanismes et etude structurale

The condensation of various iminophosphoranes with o-phthalaldehyde led directly to N-substituted isoindoline-1-ones and 3-acylisoquinolines.Three different mechanisms, depending on the nature of the iminophosphorane and reaction conditions, are proposed.All the compounds have been fully characterized, particularly by one- and two-dimensional nuclear magnetic resonance spectroscopy.

A NEW VERSATILE SYNTHESIS OF ISOQUINOLINES BY CONDENSATION OF IMINOPHOSPHORANES WITH o-PHTHALALDEHYDE

The 3-isoquinolyl ketones (2a-d) are obtained by a one-pot procedure involving condensation of o-phthalaldehyde with iminophosphoranes (1a-d) generated in situ from the corresponding organic azides.