92287-44-0

Basic information

• Product Name: Isoxazole, 5-ethenyl-4,5-dihydro-3-phenyl-
• CAS NO: 92287-44-0
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Mol File: 92287-44-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Isoxazole, 5-ethenyl-4,5-dihydro-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 5-ethenyl-4,5-dihydro-3-phenyl-(92287-44-0)
• EPA Substance Registry System: Isoxazole, 5-ethenyl-4,5-dihydro-3-phenyl-(92287-44-0)

Safety Data

• Hazardous Substances Data: 92287-44-0(Hazardous Substances Data)

Upstream product

• 873-67-6 benzonitrile oxide 
• 106-99-0 buta-1,3-diene 
• 821-06-7 (E)-1,4-dibromobutene 
• 109787-95-3 1-phenyl-1-oxo-3-hydroxypent-4-ene 
• 613-91-2 acetophenone oxime 
• 59239-04-2 1-phenyl-4-penten-1-one oxime 
• 98-86-2 acetophenone 

Downstream Products

• 89543-99-7 erythro-5'-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-phenylisoxazoline 
• 89543-99-7 threo-5'-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-phenylisoxazoline 
• 106272-35-9 ethyl (E)-3-(3-phenyl-isoxazolin-5-yl)acrylate 
• 1241681-13-9 1-amino-1-phenylpentan-3-ol 
• 6501-72-0 (S,R)-3-phenyl-4,5-dihydro-5-isoxasoleacetic acid 
• 89543-87-3 1-(3-phenyl-isoxazolin-5-yl)ethane-1,2-diol 
• 98-86-2 acetophenone 
• 107-02-8 acrolein 

Relevant articles and documents

Synthesis of 5-Vinyl-2-isoxazolines by Palladium-Catalyzed Intramolecular O-Allylation of Ketoximes

An efficient method for the synthesis of 5-vinyl-2-isoxazolines by Pd-catalyzed intramolecular O-allylation of ketoximes has been developed. The reaction involves Pd(0)-catalyzed π-allyl formation via leaving group ionization or Pd(II)-catalyzed allylic C-H activation followed by intramolecular nucleophilic oxime oxygen attack. This methodology has been elaborated to various value-added products by epoxidation, Wacker oxidation, cross-metathesis, hydroboration-oxidation, dihydroxylation, and catalytic hydrogenation.

Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin

A palladium-catalyzed efficient synthesis of 5-methylisoxazoles via oxime-mediated functionalization of unactivated olefins is described. The reaction affords a variety of 5-methylisoxazoles in moderate to good yields. To further demonstrate the utility of the method, the rapid synthesis of valdecoxib and oxacillin is reported. (Chemical Equation Presented).