92552-99-3

Upstream product

• 93-07-2 Veratric acid 
• 95-55-6 2-amino-phenol 
• 95-51-2 o-chloroaniline 
• 374695-15-5 2-(3',4'-dihydroxyphenyl)benzothiazole 
• 74-88-4 methyl iodide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 273-53-0 benzoxazole 
• 101959-15-3 3,4-dimethoxyphenyl methanesulfonate 
• 2033-89-8 3,4-dimethoxyphenol 
• 80241-83-4 N**2-(3,4-dimethoxy-benzylidene)aminophenol 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 88-75-5 2-hydroxynitrobenzene 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 895154-77-5 tris(3,4-dimethoxyphenyl)bismuthane 

Downstream Products

• 1042719-91-4 2-[2-phenyl-4,5-dimethoxyphenyl]-1,3-benzoxazole 
• 1042719-92-5 2-[2-(4-methylphenyl)-4,5-dimethoxyphenyl]-1,3-benzoxazole 
• 1315571-22-2 2-(benzoxazol-2-yl)-4,5-dimethoxyphenyl acetate 

Relevant academic research and scientific papers

Environmental benign synthesis of novel double layered nano catalyst and their catalytic activity in synthesis of 2-substituted benzoxazoles

Synthesis of Cu-Al hydrotalcite by co precipitation method is being described. Synthesized nano catalyst has been characterized by powder X-ray diffraction, scanning electron microscopy, FT-IR and thermogravimetric analyses which confirm hydrotalcite-like structure. Effect of molar concentration, catalyst loading, reaction time and catalytic activity have been investigated in the synthesis of benzoxazoles under solvent free conditions using 2-amino phenol and benzoyl chloride. The influence of the hydrotalcite and their different amounts on reactivity was studied. Catalyst can be recycle and used for further reaction without losing its activity.

Synthesis, Characterization and DFT-D Studies of 2-Aminoethoxycalix[4]resorcinarenes: A Novel Heterogeneous Organocatalyst

The present article reports the synthesis of two novel supramolecular architectures, Phenyl(octa-2-aminoethoxy)calix[4]resorcinarene and 2-Aminoethoxyphenyl-(octa-2-aminoethoxy)calix[4]resorcinarene via surface functionalization and describes their applic

Development of homogeneous polyamine organocatalyst for the synthesis of 2-aryl-substituted benzimidazole and benzoxazole derivatives

A new polyamine was prepared by the ring opening polymerization of epichlorohydrin and properly characterized. The catalytic property of the prepared polymer was assessed by synthesizing 2-aryl-substituted benzimidazole and benzoxazole derivatives by the conjugation of o-phenylenediamine/o-aminophenol with various aromatic aldehydes in the presence of atmospheric oxygen. Significant attributes of the present synthesis include short reaction time, good to excellent yield, high purity, easy reusability, and room temperature reaction. The reaction was carried out in the absence of any metal catalyst and other cooxidants.

Iron-Catalyzed Sulfur-Promoted Decyanative Redox Condensation of o-Nitrophenols and Arylacetonitriles: An Unprecedented Route to 2-Arylbenzoxazoles

Elemental sulfur in the presence of a catalytic amount of FeCl2·4H2O was found to be highly efficient for the promotion of decyanative redox condensation reactions of o-nitrophenols with arylacetonitriles, to give a wide range of 2-arylbenzoxazoles. The utility of elemental sulfur was highlighted by its role as cyanide scavenger and external reducing agent.

A green approach to the synthesis of a nano catalyst and the role of basicity, calcination, catalytic activity and aging in the green synthesis of 2-aryl bezimidazoles, benzothiazoles and benzoxazoles

A green synthesis of hydrotalcite (a double layered catalyst) by a grinding method using Al/Mg molar ratios of 1.0-3.0 at room temperature is described. The prepared double layered catalyst (hydrotalcite) has been characterized by TG, FT-IR, SEM, XRD and Hammett titration methods. Different factors such as the effect of molar ratios, catalyst loading, reaction time, aging time, and basicity have been investigated for the facile, efficient and green synthesis of 2-arylbenzimidazoles, benzothiazoles and benzoxazoles under solvent free conditions. The influence of catalyst loading on reactivity was studied and a catalyst loading of 20 mg was found to be optimal, giving the best yield with minimum time as compared to other catalysts. The present methodology reports, herein, a rapid and cost effective synthesis of hydrotalcite and its versatile applications in the synthesis of 2-arylbenzimidazoles, benzothiazoles and benzoxazoles.

Catalyst-free microwave-promoted one pot synthesis of 2-aryl benzoxazoles using MnO2 nanoparticles as a convenient oxidant under mild condition

Abstract: An efficient and facile protocol for one pot synthesis of a series of 2-aryl benzoxazoles through coupling of o-aminophenol with aromatic aldehydes under microwave irradiation in the presence of MnO2 nanoparticles as oxidant reagent was demonstrated. The MnO2 nanoparticles were prepared via a solid-state chemical reaction technique. The structure of oxidant was assigned by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The target molecules were obtained in good to high yields, high purity and short reaction times. The pure products were identified and characterized by physical and spectral data such as; melting point, IR, 1H NMR and 13C NMR. Graphical Abstract: An efficient and facil protocol for one pot synthesis of a series of 2-aryl benzoxazoles through coupling of o-aminophenol with aromatic aldehydes under microwave irradiation in the precense of MnO2 nanoparticles as oxidant reagent was demonstrated.

Sonocatalyzed facile synthesis of 2-aryl benzoxazoles using MnO2 nanoparticles as oxidant agent under mild conditions

Nano MnO2 was found to be an efficient oxidant agent for the synthesis of 2-substituted benzoxazoles through one-pot reaction of o-aminophenol and different aromatic aldehydes in acetonitrile under ultrasonic irradiation. This method was performed under mild conditions with high yields, inexpensive and readily available oxidant agent, facile and easy experimental procedure, simple purification of final products, and short reaction times. The prepared nano MnO2 has been characterized by FTIR, XRD, and SEM techniques. The pure products were identified and characterized by physical and spectroscopic data such as; melting point, IR, 1H NMR, and 13C NMR.

OMS-2/H2O2/Dimethyl Carbonate: An Environmentally-Friendly Heterogeneous Catalytic System for the Oxidative Synthesis of Benzoxazoles at Room Temperature

A manganese octahedral molecular sieve (OMS-2) was found to be an efficient and recyclable heterogeneous catalyst for the oxidative synthesis of benzoxazoles in the gram-scale from phenolic imines at room temperature. H2O2 and biobased reagent dimethyl carbonate (DMC) were successfully employed as the environmentally friendly oxidant and solvent, respectively, in an OMS-2-catalysted redox reaction for the first time. Benzoxazoles could also be obtained from N-substituted 2-aminophenols via Cu(OH)x/OMS-2-catalyzed sequential oxidative transformation at elevated temperatures.

Atom economic palladium catalyzed novel approach for arylation of benzothiazole and benzoxazole with triarylbismuth reagents via C[sbnd]H activation

We have developed a novel method for the direct C[sbnd]H functionalization of benzothiazole and benzoxazole using triarylbismuth reagents. The arylation proceeds using the homogeneous catalytic system PdCl2, Cu(OAc)2 and PPh3 ligand. Triarylbismuthines, which act as threefold arylating reagents, have low toxicity, are green and ecofriendly. These methodologies are particularly useful to prepare arylated benzothiazoles and benzoxazoles.

N-Heterocyclic carbene copper(i) complex-catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles

A new and efficient synthesis of 2-arylbenzoxazoles and benzothiazoles using a copper N-heterocyclic carbene complex is described. In a simple protocol a variety of 2-substituted benzoxazoles and benzothiazoles were obtained via intramolecular coupling cyclization of 2-haloanilides/2-halothioanilides in good to excellent yields.