928-81-4

Usage

Uses

Used in Pharmaceutical Industry:
6-Oxohexanoic acid is used as an active pharmaceutical ingredient for the development of drugs targeting specific diseases. Its unique structure allows it to interact with biological targets, making it a promising candidate for drug discovery and development.
Used in Cosmetic Industry:
6-Oxohexanoic acid is used as a key ingredient in cosmetic formulations for its moisturizing and skin-conditioning properties. It helps to maintain the skin's natural moisture balance and provides a smooth texture, making it suitable for various cosmetic products.
Used in Food Industry:
6-Oxohexanoic acid is used as a flavoring agent in the food industry. Its unique taste profile can enhance the flavor of various food products, making it a valuable addition to the food and beverage sector.
Used in Chemical Industry:
6-Oxohexanoic acid is used as a building block for the synthesis of various chemical compounds. Its versatile structure allows it to be used in the production of specialty chemicals, polymers, and other materials.
Used in Research and Development:
6-Oxohexanoic acid is used as a research tool in various scientific studies. Its unique properties make it an interesting subject for research in fields such as biochemistry, pharmacology, and materials science.

InChI:InChI=1/C6H10O3/c7-5-3-1-2-4-6(8)9/h5H,1-4H2,(H,8,9)

Upstream product

• 111-50-2 Adipic acid dichloride 
• 108-94-1 cyclohexanone 
• 74515-80-3 2,9,15,16,17,18-Hexaoxa-tricyclo[8.4.2.2^3,8]octadecane 
• 1792-81-0 cis-1,2-cyclohexane 
• 1191-25-9 6-Hydroxyhexanoic acid 
• 110-82-7 cyclohexane 
• 1577-22-6 5-hexenoic acid 
• 124-04-9 Adipic acid 
• 110-83-8 cyclohexene 
• 286-20-4 cyclohexane-1,2-epoxide 
• 1460-57-7 trans-1,2-cyclohexandiol 
• 533-60-8 cyclohexanone-2-ol 

Downstream Products

• 110-94-1 1,5-pentanedioic acid 
• 124-04-9 Adipic acid 
• 110-15-6 succinic acid 
• 60-32-2 6-aminohexanoic acid 
• 1191-25-9 6-Hydroxyhexanoic acid 
• 57-08-9 6-(acetylamino)hexanoic acid 
• 627-93-0 hexanedioic acid dimethyl ester 
• 1119-40-0 Dimethyl glutarate 
• 1072-21-5 hexanedial 
• 629-11-8 1,6-hexanediol 
• 7259-78-1 7-oxa-1,13-tridecanediol 
• 6654-36-0 methyl 6-oxohexanoate 

Relevant academic research and scientific papers

Routes of Formation of Bifunctional C6 Carboxylic Acids in the Cyclohexane Oxidation Process

Abstract: The buildup kinetics of the main and side products during uncatalyzed and cobalt naphthenate-catalyzed oxidation of cyclohexane at 150°C have been studied. 6-Hydroxyhexanoic, 6-oxohexanoic, and adipic acids are accumulated in parallel during the oxidation of cyclohexane, cyclohexanone, and 2-hydroxycyclohexanone. The critical consideration of their known formation pathways and the reactivity of possible precursors gives evidence for the predominant formation of 6-hydroxyhexanoic acid at the step of cyclohexanol oxidation and adipic acid from 2-hydroxycyclohexanol.

ALDEHYDE-SELECTIVE WACKER-TYPE OXIDATION OF UNBIASED ALKENES

This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising: (a) a dichloro-palladium complex; (b) a copper complex; (c) a source of nitrite; under aerobic reaction conditions sufficient to convert at least a portion of the terminal olefin to an aldehyde.

Perspectives on the kinetics of diol oxidation over supported platinum catalysts in aqueous solution

The catalytic oxidation of a variety of terminal alcohols was performed over Pt/C with 10 bar dioxygen at 343 K in aqueous solvent at low pH. The influences of Pt particle size, carbon support, alcohol structure, and start-up conditions were explored. Although the turnover frequency was not affected by particle size or the carbon support, the structure of the alcohols affected their initial rate of conversion. Both the rate of oxidation of α,ω-diols and selectivity of the diols to the diacids increased with increasing carbon chain length. The rate of 1,6-hexanediol oxidation was independent of dioxygen pressure and the order of reaction with respect to diol concentration depended on the start-up conditions. A kinetic model involving two types of metal sites was proposed to account for the experimental observations.

Aldehyde-selective wacker-type oxidation of unbiased alkenes enabled by a nitrite co-catalyst

Breaking the rules: Reversal of the high Markovnikov selectivity of Wacker-type oxidations was accomplished using a nitrite co-catalyst. Unbiased aliphatic alkenes can be oxidized with high yield and aldehyde selectivity, and several functional groups are tolerated. 18O-labeling experiments indicate that the aldehydic O atom is derived from the nitrite salt. Copyright

METHOD FOR PRODUCING OXYGEN-CONTAINING COMPOUND

[Problem] There is provided a method for producing an oxygen-containing compound safely and with improved reaction efficiency, in which an undesired peroxide is unlikely to be produced, and efficient heat exchange of the ozonization can be achieved. [Mean for solving the Problem] The method comprises an ozonization reaction step of continuously supplying, together with an organic compound, ozone having an oxygen content of less than 10% in a dissolved state in high-pressure carbon dioxide to an ozonization reaction section having a thin tubular shape, and reacting the ozone and the organic compound under conditions that suppress generation of oxygen due to thermal decomposition of the ozone, thereby continuously producing an ozonide; and a decomposition reaction step of continuously supplying the ozonide produced in the ozonization reaction step to a decomposition reaction section having a thin tubular shape, thereby continuously producing an oxygen-containing compound, the decomposition reaction step being provided in a manner continuous with the ozonization reaction step.

Mechanistic insights into the conversion of cyclohexene to adipic acid by H2O2 in the presence of a TAPO-5 catalyst

The stereochemistry of the 1,2-cyclohexanediol intermediate plays an important role with regard to both the rate and selectivity of the production of adipic acid from cyclohexene in the absence of an organic solvent. A titanium-containing aluminophosphate molecular sieve (TAPO-5) is shown to serve as a good heterogeneous catalyst for this reaction.

Oxidation of 2-Methylcyclohexanone and Cyclohexanone by Dioxygen Catalyzed by Vanadium-Containing Heteropolyanions

2-Methylcyclohexanone is oxidized by dioxygen in the presence of H(3+n)*aq to give 6-oxoheptanoic acid.Solvent effects are studied.The same precursors with cyclohexanone in aqueous acetic acid give adipic acid as the major product and other dicarboxylic acids by oxidation of 6-oxohexanoic acid.

HETEROPOLYANIONS AS OXIDATION CATALYSTS IN A 2-PHASE SYSTEM

Described is a system using heteropoly-11-tungstates as homogeneous catalysts for the oxidation of cyclohexene with hydrogen peroxide.The catalyst is dissolved in an organic solvent while the oxidant resides in the aqueous phase.The oxidation efficiency is high.

FORMATION OF epsilon -CAPROLACTONE DURING OXIDATION OF CYCLOHEXANONE.

It was suggested in earlier studies of the mechanism of cyclohexanone oxidation that formation of CL results from oxidation of cyclohexanone by the intermediate monoperoxyadipic acid by the Baeyer-Villiger reaction. Certain evidence in support of this route of lactone formation has been obtained only recently. Additional data on the probability of reaction are presented, and the possibility of suppressing the reaction is discussed. It is shown that it is possible in principle to suppress formation of an important byproduct of cyclohexanone oxidation, namely epsilon -caprolactone, by introducing a reagent which decomposes monoperoxyadipic acid selectively into the reaction medium.

OXIDATION OF CYCLOHEXANONE AND 2-HYDROXYCYCLOHEXANONE IN PRESENCE OF CHROMIUM NAPHTHENATE.

A comparison of the kinetics of accumulation of the products of oxidation of cyclohexanone and 2-hydroxycyclohexanone in presence of chromium and cobalt naphthenates and in absence of catalysts showed that the composition of the reaction products varies considerably with the nature of the catalytic metal. In distinction from polymethylene hydrocarbons, which form carbonyl compounds, cyclohexanone is concerted in presence of chromium salts predominantly through 2-hydrocyclohexanone. Oxidation of cyclohexanone and 2-hydroxycyclohexanone in presence of chromium naphthenate gives lower yields of 1,2-cyclohexanedione than the noncatalytic reaction or the reaction catalyzed by cobalt napthenate.