928325-25-1

Basic information

• Product Name: 5-(2-fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde
• Synonyms: 5-(2-fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde
• CAS NO: 928325-25-1
• Molecular Weight: 330.339
• Mol File: 928325-25-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(2-fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde(928325-25-1)
• EPA Substance Registry System: 5-(2-fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde(928325-25-1)

Safety Data

• Hazardous Substances Data: 928325-25-1(Hazardous Substances Data)

Upstream product

• 881673-82-1 5-bromo-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde 
• 174669-73-9 (2-fluoro-pyridin-3-yl)boronic acid 
• 7126-39-8 pyrrole-3-carboxaldehyde 
• 98-09-9 benzenesulfonyl chloride 
• 881676-32-0 5-bromo-1H-pyrrole-3-carboxaldehyde 

Downstream Products

• 1055306-26-7 1-[(2-fluorophenyl)sulfonyl]-5-(2-fluoropyridin-3-yl)-1H-pyrrole-3-carbaldehyde 
• 1055306-28-9 5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde 
• 1055306-31-4 4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde 
• 1055304-71-6 1-{1-[(2-fluorophenyl)sulfonyl]-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl}-N-methylmethanamine fumarate 
• 1055304-75-0 1-(5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)-N-methylmethanamine fumarate 
• 1055304-81-8 1-(4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)-N-methylmethanamine fumarate 
• 1055304-69-2 1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate 
• 928325-26-2 5-(2-fluoropyridin-3-yl)-1H-pyrrole-3-carbaldehyde 

Relevant articles and documents

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action

With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative 1b as a lead compound. As part of

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.