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Upstream product

• 100-52-7 benzaldehyde 
• 108-42-9 3-chloro-aniline 
• 122-52-1 triethyl phosphite 
• 78-40-0 triethyl phosphate 
• 31682-65-2 diethyl phosphite 
• 762-04-9 phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Catalyst free one-pot synthesis of α-aminophosphonates in aqueous ethyl lactate

An highly efficient and environmentally friendly process for the synthesis of α-aminophosphonates has been devised, through a one-pot three-component condensation of various aldehydes, amines and triethyl phosphate in water-ethyl lactate under ultrasonic

A simple protocol for the synthesis of α-substituted phosphonates

An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.

A Green Approach to the Synthesis of α-Amino Phosphonate in Water Medium: Carbene Insertion into the N-H Bond by Cu(I) Catalyst

Synthesis of amino phosphonates is more important owing to their significant applications in the biological systems. There are few methods already known in the literature to make these molecules; however, known methods have their own disadvantages. In this regard, synthesis of different kinds of amino phosphonates have been achieved via phosphonate substituted carbene insertion into the N-H bond of aniline catalyzed by readily available copper salt under mild reaction conditions in water. In order to find an efficient catalyst for carbene insertion reaction in neat water, a large number of transition metal catalysts were screened, and we found that the [Cu(CH3CN)4]ClO4 was the best catalyst under employed reaction conditions. Using this environmentally benign methodology (copper catalyzed reaction in water), a large number of biologically important amino phosphonates have been synthesized, isolated (37 examples), and characterized using standard analytical and spectroscopic techniques.

Highly efficient one-pot synthesis of α-aminophosphonates catalyzed by ytterbium triflate in water

A facile one-pot, three-component synthesis of α-aminophosphonates catalyzed by ytterbium triflate [Yb(OTf)3] in water using polyoxyethanyl α-tocopheryl sebacate (PTS) as amphiphile has been developed. The catalytic system could be readily recycled and reused several times without significant loss in its activity.

TfOH/C-catalyzed one-pot three-component synthesis of α-amino phosphonates under solvent-free conditions

The TfOH/C was readily prepared via simple absorption of triflic acid onto activated charcoal. This solid acid was used as an efficient catalyst for the synthesis of α-aminophosphonates through the Kabachnik-Fields reaction of carbonyl compound, amine and

Magnetic nanoparticles coated by acidic functionalized poly(amidoamine) dendrimer: Effective acidic organocatalyst

A novel magnetic Br?nsted acid catalyst was synthesized based on growing poly(amidoamine) dendrimers on the surface of magnetic nanoparticles. After the dendronizing process, the MNP coated PAMAM was functionalized by chlorosulfuric acid to form an acid catalyst. Because of dendrimer coating of MNPs, catalyst shows good loading level of acidic groups on the surface. Also zwitterion nature of catalyst surface improves the catalytic activity. This new catalyst is proven to be highly effective in the synthesis of α-aminophosphonate compounds in a green way.

A facile synthesis of α-aminophosphonates catalyzed by ytterbium perfluorooctanoate under solvent-free conditions

Three-component reactions of aldehydes, amines and diethyl phosphite are efficiently catalyzed by ytterbium perfluorooctanoate [Yb(PFO)3] under solvent-free conditions, giving the corresponding α- aminophosphonates in good to excellent yields. The catalyst can be recovered and reused for several times without any significant loss of activity. Furthermore, a possible mechanism for this transformation is also presented.

CeCl37H2O-catalyzed one-pot Kabachnik-Fields reaction: A green protocol for three-component synthesis of α- aminophosphonates

CeCl37H2O has been utilized as an efficient Lewis acid catalyst for the three-component coupling of aldehydes, aromatic amines, and diethylphosphite to produce α-aminophosphonates under solvent-free conditions. The advantages of this protocol are high yield, mild reaction conditions, less environmental pollution, and simple work-up procedure.

ZrOCl2·8H2O: An efficient catalyst for one-pot synthesis of α-amino phosphonates under solvent-free conditions

A highly efficient protocol has been developed for the three-component reaction of an amine, an aldehyde, and diethyl phopshite catalyzed by ZrOCl2·8H2O, an environmentally friendly catalyst, at ambient temperature. The catalyst exhibited remarkable activ