98065-14-6

Usage

Uses

Used in Recreational Drug Industry:
1-(1-phenylpropyl)Piperidine is used as a recreational drug for its euphoric and stimulant effects. It is sought after for its ability to produce a sense of euphoria and increased energy, making it a popular choice among those seeking a temporary escape from reality.
However, it is important to note that 1-(1-phenylpropyl)Piperidine is considered to have a high potential for abuse and addiction, and its use can lead to a range of adverse health effects, including cardiovascular and psychiatric problems. Due to these risks, the substance is regulated in many countries to prevent misuse and protect public health.

Upstream product

• 2591-86-8 N-Formylpiperidine 
• 93-55-0 1-phenyl-propan-1-one 
• 5766-79-0 2-phenyl-2-piperidinoacetonitrile 
• 925-90-6 ethylmagnesium bromide 
• 110-89-4 piperidine 
• 557-20-0 diethylzinc 
• 2238-12-2 1-(methoxy(phenyl)methyl)piperidine 
• 100-52-7 benzaldehyde 
• 25076-80-6 α-Piperidino-β-methyl styrene 
• 23022-83-5 1-bromo-1-phenyl-2-propanone 
• 19134-53-3 1-phenyl-1-piperidin-1-yl-propan-2-one 

Relevant academic research and scientific papers

Atom-efficient transition-metal-free arylation ofN,O-acetals using diarylzinc reagents through Zn/Zn cooperativity

Exploiting the cooperative action of Lewis acid Zn(C6F5)2with diarylzinc reagents, the efficient arylation ofN,O-acetals to access diarylmethylamines is reported. Reactions take place under mild reaction conditions without the need for transtion-metal catalysis. Mechanistic investigations have revealed that Zn(C6F5)2not only acts as a Lewis acid activator, but also enables the regeneration of nucleophilic ZnAr2species, allowing a limiting 50 mol% to be employed.

Phosphine-Borane Frustrated Lewis Pairs Derived from a 1,1′-Disubstituted Ferrocene Scaffold: Synthesis and Hydrogenation Catalysis

(Dimesitylphosphino)ferrocene (FcPMes2) (1) reacted with HB(C6F5)2 (2 equiv) by disproportionation to give adduct FcPMes2·H2B(C6F5) (4) plus B(C6F5)3, whereas 1-(dimesitylphosphino)-1′-vinylferrocene (2) was cleanly hydroborated with HB(C6F5)2 to afford [Fe(??5-C5H4PMes2)(??5-C5H4CH2CH2B(C6F5)2)] (7). Compound 7 adopted an open non-interacting P/B frustrated Lewis pair (FLP) structure in the crystal state as well as in a solution. This frustrated Lewis pair heterolytically cleaved dihydrogen under mild conditions to give the respective zwitterionic [P]H+/[B]H- phosphonium/hydroborate product, [Fe(??5-C5H4PHMes2){??5-C5H4CH2CH2BH(C6F5)2}] (8), which served as a catalyst for the hydrogenation of the electron-rich ?€-systems (imine, enamine) as well as the electron-deficient carbon-carbon double and triple bonds in some enones and an ynone under more forcing conditions (50 bar H2 pressure, 50 °C).

A Synthesis of α-Substituted Amines

The reaction of amides with organolithium reagents followed by hydride reducing agents has been studied as a synthetic route to α-substituted amines.The stereochemistry of the amine has been observed to depend upon the nature of the reducing agent.