93022-29-8

Upstream product

• 673-32-5 1-Phenylprop-1-yne 
• 65-85-0 benzoic acid 
• 833-81-8 1,2-diphenylpropene 
• 124-38-9 carbon dioxide 
• 63904-72-3 (E)-(1-bromoprop-1-ene-1,2-diyl)dibenzene 
• 63904-73-4 (Z)-(1-bromoprop-1-ene-1,2-diyl)dibenzene 
• 33148-55-9 2-(2-phenylacetyl)benzoic acid 
• 92873-95-5 (RS)-3-((SR)-α-chloro-benzyl)-3-methyl-phthalide 
• 86977-54-0 3-benzyl-3-methylisobenzofuran-1(3H)-one 

Downstream Products

• 101278-19-7 3-benzoyl-3-methyl-phthalide 
• 101110-08-1 2-((1RS,2RS)-2-hydroxy-1-methyl-2-phenyl-ethyl)-benzoic acid-lactone 

Relevant academic research and scientific papers

Remote sp2C-H Carboxylation via Catalytic 1,4-Ni Migration with CO2

A remote catalytic reductive sp2 C-H carboxylation of arenes with CO2 (1 bar) via 1,4-Ni migration is disclosed. This protocol constitutes the first catalytic 1,4-Ni migration reported to date, thus offering new vistas in the Ni-catalyzed reductive coupling arena while providing an unconventional new platform for incorporating electrophilic sites at remote sp2 C-H linkages.

Doubly Regioselective C-H Hydroarylation of Unsymmetrical Alkynes Using Carboxylates as Deciduous Directing Groups

A catalyst system composed of [(C6Me6)RuCl2]2, potassium carbonate/guanidine carbonate, and mesitoic acid efficiently promotes the doubly regioselective C-H hydroarylation of unsymmetrical alkynes. The process involves carboxylate-directed ortho-C-H bond activation followed by regioselective addition to the alkyne C-C triple bond with concerted decarboxylation. This action of the carboxylate as a deciduous directing group ensures exclusive monovinylation with high selectivity for the (E)-1,2-diarylalkene.