93074-72-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-quinoline-3-carboxylic acid ethyl ester is used as a potential drug candidate for its antimalarial and antiparasitic properties. It is particularly valuable for the treatment of malaria and other parasitic infections due to its increased solubility and ease of administration compared to its parent compound.
Used in Research and Development:
4-Amino-quinoline-3-carboxylic acid ethyl ester is used as a subject of interest in the field of infectious diseases research and development. Its pharmacological properties and potential applications are being explored to further understand its efficacy and safety in treating various parasitic infections.
Used in Drug Formulation:
4-Amino-quinoline-3-carboxylic acid ethyl ester is used in the formulation of pharmaceutical products, leveraging its enhanced solubility to improve the bioavailability and effectiveness of antimalarial and antiparasitic medications. This can lead to the development of more potent and targeted therapies for these diseases.

InChI:InChI=1/C12H12N2O2/c1-2-16-12(15)9-7-14-10-6-4-3-5-8(10)11(9)13/h3-7H,2H2,1H3,(H2,13,14)

Upstream product

• 13720-94-0 ethyl 4-chloroquinoline-3-carboxylate 
• 141-97-9 ethyl acetoacetate 
• 105-53-3 diethyl malonate 
• 141-52-6 sodium ethanolate 
• 1885-29-6 anthranilic acid nitrile 

Downstream Products

• 68313-46-2 acide amino-4 quinoleinecarboxylique-3 

Relevant academic research and scientific papers

Superacidic Cyclization of Activated Anthranilonitriles into 2-Unsubstituted-4-aminoquinolines

4-Aminoquinolines were prepared in a three-step synthesis starting from substituted anthranilonitriles. The condensation on 1,1,1-trichloro-4-ethoxybut-3-enone proceeded efficiently either neat or in refluxing EtOH. Cyclization in superacidic trifluoromethanesulfonic acid provided unstable intermediate, which upon treatment with NaOEt in ethanol, afforded the expected esters. Theoretical investigations pointed out a monoprotonated nitrilium as the reactive species during the cyclization process.

A new [5+1]-annulation route to some quinazoline and fused pyrimidine derivatives

β-Dicarbonyl compounds, such as diethyl malonate, ethyl acetoacetate and acetyl acetone have been found to add selectively to the iminoether functionality of the 2-ethoxymethyleneaminonitriles leading to a one-pot synthesis of some quinazoline and fused p

HETEROCYCLIC DERIVATIVES FOR TREATMENT OF HYPERLIPIDEMIA AND RELATED DISEASES

The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of hypercholesterolemia, atherosclerosis and associated

Synthesis of 4-substituted aminoquinoline-3-carboxylates as potential antimicrobial agents

A series of 4-substituted aminoquinoline-3-carboxylates was prepared and evaluated for antimicrobial activity. Four of the compounds (VIII, XIII, XV, and XXIII) exhibited low activity against Staphylococcus aureus.