93307-66-5Relevant academic research and scientific papers
Rh(I)-catalyzed cross-coupling of α-diazoesters with arylsiloxanes
Xia, Ying,Liu, Zhen,Feng, Sheng,Ye, Fei,Zhang, Yan,Wang, Jianbo
supporting information, p. 956 - 959 (2015/03/30)
An Rh(I)-catalyzed cross-coupling of diazoesters with arylsiloxanes has been successfully achieved. This transformation is a new method for the construction of the C(sp3)-C(sp2) bond, thus providing an alternative synthesis of α-aryl esters. Rh(I)-carbene migratory insertion has been proposed to be involved in this coupling reaction. The reaction represents the first example of utilizing arylsiloxane as the coupling partner in the carbene-involved cross-coupling reactions.
3-aryl-6-methoxy-2-oxo-1,2-dihydroquinoline-4-carbonitriles as solvent and pH independent green fluorescent dyes
Enoua, Guy Crepin,Uray, Georg,Stadlbauer, Wolfgang
, p. 1415 - 1421 (2013/02/22)
Highly fluorescent and stable 3-aryl-6-methoxy-2-oxoquinoline-4- carbonitriles 6 (λexc = 408 nm and λem = 510 nm) were synthesized starting from appropriate arylmalonates 2. Ring closure reaction with p-anisidine gave 4-hydroxyquinol
4-Amino-5-aryl-6-arylethynylpyrimidines: Structure-activity relationships of non-nucleoside adenosine kinase inhibitors
Matulenko, Mark A.,Paight, Ernest S.,Frey, Robin R.,Gomtsyan, Arthur,DiDomenico Jr., Stanley,Jiang, Meiqun,Lee, Chih-Hung,Stewart, Andrew O.,Yu, Haixia,Kohlhaas, Kathy L.,Alexander, Karen M.,McGaraughty, Steve,Mikusa, Joseph,Marsh, Kennan C.,Muchmore, Steven W.,Jakob, Clarissa L.,Kowaluk, Elizabeth A.,Jarvis, Michael F.,Bhagwat, Shripad S.
, p. 1586 - 1605 (2008/02/01)
A series of non-nucleoside adenosine kinase (AK) inhibitors is reported. These inhibitors originated from the modification of 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine (ABT-702). The identification of a linker that would approximate the spatial arrangement found between the pyrimidine ring and the aryl group at C(7) in ABT-702 was a key element in this modification. A search of potential linkers led to the discovery of an acetylene moiety as a suitable scaffold. It was hypothesized that the aryl acetylenes, ABT-702, and adenosine bound to the active site of AK (closed form) in a similar manner with respect to the orientation of the heterocyclic base. Although potent acetylene analogs were discovered based on this assumption, an X-ray crystal structure of 5-(4-dimethylaminophenyl)-6-(6-morpholin-4-ylpyridin-3-ylethynyl)pyrimidin-4-ylamine (16a) revealed a binding orientation contrary to adenosine. In addition, this compound bound tightly to a unique open conformation of AK. The structure-activity relationships and unique ligand orientation and protein conformation are discussed.
AROMATIC NUCLEOPHILIC SUBSTITUTION ON η6-Cr(CO)3-COMPLEXED HALOGENOARENES: ARYLATION OF SECONDARY CARBANIONS
Baldoli, Clara,Buttero, Paola Del,Licandro, Emanuela,Maiorana, Stefano
, p. 409 - 414 (2007/10/02)
The paper deals with the aromatic nucleophilic substitution on η6-Cr(CO)3-complexed fluorobenzene and ortho-, meta-, and para-dichlorobenzenes with stabilized carbanions, both under phase-transfer conditions (PTC) and in DMSO solution.In the case of the η6-Cr(CO)3-complexed ortho-, meta-, and para-dichlorobenzenes only one chlorine atom is replaced by the carbanions.
ARYLATION OF DIETHYL MALONATE VIA NUCLEOPHILIC SUBSTITUTION REACTIONS WITH CYCLOPENTADIENYLIRON COMPLEXES OF CHLOROARENES
Abd-El-Aziz, Alaa S.,Lee, Choi Chuck,Piorko, Adam,Sutherland, Ronald G.
, p. 291 - 300 (2007/10/02)
Reaction of an η6-chloroarene-η5-cyclopentadienyliron hexafluorophosphate with diethyl malonate in the presence of K2CO3 in THF/DMSO gave a corresponding SNAr product, η6-diethyl arylmalonate-η5-cyclopentadienyliron hexafluorophosphate, which, upon pyrolic sublimation, resulted in the liberation of the arylated malonic ester.Such esters prepared in the present work included RPhCH(COOEt)2, with R = o-, m- or p-CH3, 2,6-(CH3)2, or o-, m- or p-Cl.
