934520-52-2Relevant academic research and scientific papers
Synthesis of Air- and Moisture-Stable, Storable Chiral Oxorhenium Complexes and Their Application as Catalysts for the Enantioselective Imine Reduction
Das, Braja Gopal,Nallagonda, Rajender,Dey, Dhananjay,Ghorai, Prasanta
supporting information, p. 12601 - 12605 (2015/09/01)
Air-/moisture-stable, crystalline, and storable chiral salicyloxazoline based oxorhenium(V) complexes have been synthesized and their catalytic application for the asymmetric reduction of ketimines using hydrosilane as hydride source is disclosed. A broad substrate scope, high yields, and excellent enantioselectivities (up to 99 %) are attained. Furthermore, the syntheses of enantiopure α-amino esters, γ- and δ-lactams, and isoindolinones have also been carried out using this methodology. Finally, the method has been applied to synthetic targets of pharmaceutical relevance, such as R-(+)-salsolidine and R-(+)-crispine A.
Stereocontrolled approach to δ-amino acids by asymmetric hydrogenation of 5-acetylaminopent-4-enoic acid derivatives
Starodubtseva,Turova,Antipova,Vinogradov,Sagirova,Malyshev,Struchkova
, p. 1463 - 1466 (2011/04/16)
Asymmetric hydrogenation of the C=C bond in 5-acetylamino-5-phenylpent-4- enoic acid methyl ester or N,N-dimethylamide catalyzed by rhodium complexes with chiral bisphosphine ligands (1 mol.% of the catalyst, 20 atm. of H2, MeOH, 50°C) gives the correspon
Novel intramolecular reactivity of oximes: Synthesis of cyclic and spiro-fused imines
Savarin, Cecile G.,Grise, Christiane,Murry, Jerry A.,Reamer, Robert A.,Hughes, David L.
, p. 981 - 983 (2007/10/03)
(Chemical Equation Presented) Under conventional heat (135-145°C) or microwave irradiation and 1 equiv of acetic anhydride, ortho-substituted aryl-oximes undergo a novel sp3 C-H activated cyclization to produce the corresponding isoindoles, and
The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands
Jong, Ling,Zaveri, Nurulain,Toll, Lawrence
, p. 181 - 185 (2007/10/03)
A new class of high affinity opioid and opioid receptor-like receptor (ORL1 receptor, NOP receptor) ligands has been designed by conformational restriction of piperidine-based NOP receptor ligands, resulting in a novel quinolizidine scaffold. Different mo
