935525-82-9Relevant academic research and scientific papers
A concise synthesis of maleic anhydride and maleimide natural products found in Antrodia camphorata
Stewart, Scott G.,Polomska, Marta E.,Lim, Rou Wei
, p. 2241 - 2244 (2007)
Recently, the natural products maleic anhydride 1 and maleimides 2 and 3 have been isolated from the mycelium of Antrodia Camphorata, each displaying activity in LLC cell lines. We describe a concise synthesis of each of these natural compounds utilizing C-C cross-coupling methodology, namely, the Negishi and Suzuki reactions. This efficient and high yielding synthesis is convergent lending itself to production of medicinal analogues.
