935525-83-0Relevant academic research and scientific papers
Total synthesis of (±)-camphorataimides and (±)-himanimides by NaBH4/Ni(OAc)2 or Zn/AcOH stereoselective reduction
Cheng, Chia-Fu,Lai, Zhen-Chang,Lee, Yean-Jang
, p. 4347 - 4353 (2008/09/20)
Maleic anhydride 1 of Antrodia camphorate, which can be isolated from Chinese herbal medicine, is achieved in which the longest linear sequence is only five steps, in 40% overall yield from commercially available succinic anhydride. The crucial antrodimid
A concise synthesis of maleic anhydride and maleimide natural products found in Antrodia camphorata
Stewart, Scott G.,Polomska, Marta E.,Lim, Rou Wei
, p. 2241 - 2244 (2007/10/03)
Recently, the natural products maleic anhydride 1 and maleimides 2 and 3 have been isolated from the mycelium of Antrodia Camphorata, each displaying activity in LLC cell lines. We describe a concise synthesis of each of these natural compounds utilizing C-C cross-coupling methodology, namely, the Negishi and Suzuki reactions. This efficient and high yielding synthesis is convergent lending itself to production of medicinal analogues.
