93673-13-3Relevant articles and documents
Integrated Experimental and Computational Studies on the Organocatalytic Kinetic Resolution of β-Unfunctionalized Primary Alcohols Using a Chiral 1,2-Diamine: The Importance of Noncovalent Interactions
Mori, Seiji,Ojima, Kohei,Oriyama, Takeshi,Sakai, Naoki
supporting information, p. 4468 - 4475 (2022/03/14)
The enantioselective kinetic resolution of β-unfunctionalized primary alcohols with benzoyl chloride was carried out in the presence of a catalytic amount of a novel chiral 1,2-diamine derived from (S)-proline. Several valuable chiral 2-substituted propan-1-ols were obtained with good enantioselectivities. Density functional theory calculations revealed that the noncovalent interaction, such as CH-πinteraction, is crucial for the enantioselectivity of the resolution. This study was conducted through an interplay between experiment and computation.
Easily accessible TADDOL-derived bisphosphonite ligands: Synthesis and application in the asymmetric hydroformylation of vinylarenes
Allmendinger, Simon,Kinuta, Hirotaka,Breit, Bernhard
supporting information, p. 41 - 45 (2015/03/03)
The synthesis of chiral bidentate bisphosphonite ligands based on the TADDOL motif from readily available starting materials has been developed. Taking advantage of the modular nature of the building blocks, a diverse ligand library has been prepared. Their catalytic potential has been evaluated in the asymmetric hydroformylation of styrene and derivatives. These catalysts showed high activity and provided the aldehydes in high enantiomeric purity.
Chemoenzymatic synthesis of antiinflammatory drugs in enantiomerically pure form
Basak, Amit,Nag, Ahindra,Bhattacharya, Gautam,Mandal, Subrata,Nag, Sikha
, p. 2403 - 2407 (2007/10/03)
A novel chemoenzymatic route to chiral antiinflammatory drugs in enantiomerically pure form is described. Copyright (C) 2000 Elsevier Science Ltd.
