93742-85-9

Basic information

• Product Name: 5-Fluoro-1-tetralone
• Synonyms: 5-fluoro-3,4-dihydronaphthalen-1(2H)-one;1(2H)-Naphthalenone, 5-fluoro-3,4-dihydro-;5-Fluro-1-tetralone;5-FLUORO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;5-FLUORO-1-TETRALONE;5-Fluoro-α-Tetralone;2(1H)-Naphthalenone,5-fluoro-3,4-dihydro-(9CI);5-FLUORO-A-TETRALONE
• CAS NO: 93742-85-9
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• Product Categories: HALIDE
• Mol File: 93742-85-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 265.6 °C at 760 mmHg
• Flash Point: 101.4 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 0.00906mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Fluoro-1-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-1-tetralone(93742-85-9)
• EPA Substance Registry System: 5-Fluoro-1-tetralone(93742-85-9)

Safety Data

• Hazardous Substances Data: 93742-85-9(Hazardous Substances Data)

Usage

General Description

5-Fluoro-1-tetralone is a chemical compound with the molecular formula C10H9FO. It is a fluorinated derivative of 1-tetralone, characterized by a five-membered ring structure attached to a benzene ring. The presence of a fluorine atom in its structure gives it unique reactivity that can be beneficial in various chemical reactions and syntheses, often utilized in medicinal chemistry. As a specialty chemical, it has potential applications in developing pharmaceuticals and other complex organic molecules, although it may need to be handled with care due to possible hazards associated with its use.

InChI:InChI=1/C10H9FO/c11-9-5-1-4-8-7(9)3-2-6-10(8)12/h1,4-5H,2-3,6H2

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Relevant articles and documents

KRAS G12C INHIBITORS AND USES THEREOF

The invention relates to compounds of Formula I, and pharmaceutically acceptable salts thereof, and methods of making and using the same. The compounds of the invention are effective in inhibiting KRAS protein with a G12C mutation and are suitable for use in methods of treating cancers mediated, in whole or in part, by KRAS G12C mutation.

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.

Enantioselective organocatalytic fluorination-induced Wagner-Meerwein rearrangement

Cracked under strain: Strained allylic cyclobutanols and cyclopropanols readily undergo a ring expansion described by the title rearrangement. This reaction is promoted by catalytic amounts of 1 and displays high tolerance with respect to the substrate scope. The corresponding β-fluoro spiroketone products are isolated in high yields and with excellent stereoselectivities. EDG=electron-donating group, EWG=electron-withdrawing group. Copyright