69797-46-2

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-Fluorophenyl)-4-oxobutyric acid is used as an intermediate in the synthesis of pharmaceutical drugs for its potential therapeutic applications in the treatment of various diseases and disorders.
Used in Research Chemicals:
4-(3-Fluorophenyl)-4-oxobutyric acid is used as a research chemical to study its properties and potential applications in drug discovery and development.
Used in Organic Chemistry Reactions:
4-(3-Fluorophenyl)-4-oxobutyric acid is used as a building block in organic chemistry reactions to create more complex molecules, contributing to the advancement of chemical research and the development of new compounds.

InChI:InChI=1/C10H9FO3/c11-8-3-1-2-7(6-8)9(12)4-5-10(13)14/h1-3,6H,4-5H2,(H,13,14)

Upstream product

• 66549-02-8 α-(3-fluorophenyl)-4-morpholineacetonitrile 
• 108-30-5 succinic acid anhydride 
• 17318-03-5 bromo(3-fluorophenyl)magnesium 
• 462-06-6 fluorobenzene 

Downstream Products

• 57148-29-5 3-<4-(4-chlorophenoxy)benzoyl>propionic acid 
• 70631-88-8 4-(3-fluorophenyl)butanoic acid 
• 13790-88-0 7-fluoro-1-tetralone oxime 
• 2840-44-0 7-fluoro-3,4-dihydronaphthalen-1(2H)-one 
• 93742-85-9 5-fluoro-3,4-dihydronaphthalen-1(2H)-one 
• 1270585-10-8 rac-5-(3-fluorophenyl)dihydrofuran-2(3H)-one 
• 870862-09-2 3-bromo-4-(3-fluorophenyl)-4-oxobutyric acid 

Relevant academic research and scientific papers

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.

AMINO-SUBSTITUTED AZO-HETEROCYCLIC COMPOUNDS FOR TREATING INFLAMMATORY CONDITIONS

Compounds of formula (I) are CRTH2 antagonists, useful in the treatment of inflammatory, autoimmune, respiratory or allergy disease: wherein X1 is -S-, -O-, -N=N-. -NR5-, -CR5=CR6-, -CR5=N-, wherein R5 and R6 are independently hydrogen or C1-C3 alkyl; R1 is hydrogen or C1-C3 alkyl or cyclopropyl; R2 is an optionally substituted phenyl or 5- or 6-membered monocyclic heteroaryl ring; R3 is an optionally substituted carbocyclic ring of 3 to 7 ring atoms, or an optionally substituted 4-, 5- or 6-membered monocyclic heterocyclic ring; R4 is a group other than hydrogen, methyl or ethyl of formula Q-[Alk1]m-[X]n-[Alk2]p-[Z}s- wherein m, n p, and s are independently 0 or 1 ; Q is hydrogen or an optionally substituted 4-, 5- or 6-membered monocyclic heterocyclic ring; Alk1 and Alk2 are independently optionally substituted C1-C3 alkylene radicals; X is -O-, -S-, -C(=O)-, - S(=O)-, -S(=O)2-, -CH(R7)-, -N(R7)-, or, in either orientation -SO2N(R7)- or - C(=O)N(R7)-, wherein R7 is hydrogen, or R7 represents a C2-C4 bridge between the C or N atom of X to which it is attached and a carbon atom of Alk2 and Z is -CH2, - C(=O) or -S(=O)2.

4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such an enyzme is needed. The present invention further comprises a selected class of the above mentioned 4-phenyl-4-oxo-butanoic acid derivatives, their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them.

Antihypertensive Agents: Angiotensin Converting Enzyme Inhibitors. 1--L-prolines

A series of 1--L-proline derivatives was synthesized.A number of these compounds are potent angiotensin converting enzyme (ACE) inhibitors that lowered blood pressure in aorta-coarcted renal hypertensive rats.The most active

SUBSTITUTED THIO-SUBSTITUTED BENZYL-PROPIONYL-L-PROLINES

This disclosure describes novel substituted ω-aroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.

Synthesis of 3-aminomethyl-1-tetralones as potential neuroleptic agents

3-Aminomethyl tetralones, which present the butyrophenone side chain partially incorporated in a semirigid structure have been prepared by Mannich reaction of β-benzoyl-propionic acids and heterocyclic amines, catalytic reduction of the carbonyl group and