69797-46-2

Basic information

• Product Name: 4-(3-FLUOROPHENYL)-4-OXOBUTYRIC ACID
• Synonyms: 4-(3-FLUOROPHENYL)-4-OXOBUTYRIC ACID;4-(3-fluorophenyl)-4-oxobutanoic acid
• CAS NO: 69797-46-2
• Molecular Formula: C₁₀H₉FO₃
• Molecular Weight: 196.18
• Mol File: 69797-46-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 86-88°C
• Boiling Point: 367.3°C at 760 mmHg
• Flash Point: 175.9°C
• Appearance: /
• Density: 1.283g/cm³
• Vapor Pressure: 4.85E-06mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 4-(3-FLUOROPHENYL)-4-OXOBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-FLUOROPHENYL)-4-OXOBUTYRIC ACID(69797-46-2)
• EPA Substance Registry System: 4-(3-FLUOROPHENYL)-4-OXOBUTYRIC ACID(69797-46-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 69797-46-2(Hazardous Substances Data)

Usage

General Description

4-(3-Fluorophenyl)-4-oxobutyric acid is a chemical compound with the molecular formula C10H9FO3. It is a derivative of butyric acid that contains a fluoro-substituted phenyl ring and a ketone functional group. 4-(3-FLUOROPHENYL)-4-OXOBUTYRIC ACID is commonly used in the synthesis of pharmaceutical drugs and research chemicals. It has been found to have potential therapeutic applications in the treatment of various diseases and disorders. Additionally, it is used as a building block in organic chemistry reactions to create more complex molecules. Its specific properties and uses make it a valuable tool in drug discovery and development efforts.

InChI:InChI=1/C10H9FO3/c11-8-3-1-2-7(6-8)9(12)4-5-10(13)14/h1-3,6H,4-5H2,(H,13,14)

Upstream product

• 66549-02-8 α-(3-fluorophenyl)-4-morpholineacetonitrile 
• 108-30-5 succinic acid anhydride 
• 17318-03-5 bromo(3-fluorophenyl)magnesium 
• 462-06-6 fluorobenzene 

Downstream Products

• 70631-88-8 4-(3-fluorophenyl)butanoic acid 
• 13790-88-0 7-fluoro-1-tetralone oxime 
• 2840-44-0 7-fluoro-3,4-dihydronaphthalen-1(2H)-one 
• 93742-85-9 5-fluoro-3,4-dihydronaphthalen-1(2H)-one 
• 1270585-10-8 rac-5-(3-fluorophenyl)dihydrofuran-2(3H)-one 
• 57148-29-5 3-<4-(4-chlorophenoxy)benzoyl>propionic acid 
• 870862-09-2 3-bromo-4-(3-fluorophenyl)-4-oxobutyric acid 

Relevant articles and documents

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.

4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such an enyzme is needed. The present invention further comprises a selected class of the above mentioned 4-phenyl-4-oxo-butanoic acid derivatives, their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them.

SUBSTITUTED THIO-SUBSTITUTED BENZYL-PROPIONYL-L-PROLINES

This disclosure describes novel substituted ω-aroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.