99725-13-0

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Bromo-2-fluorobenzylamine hydrochloride is utilized as a key building block in the creation of diverse pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the realm of organic synthesis, 5-Bromo-2-fluorobenzylamine hydrochloride serves as an important intermediate. It is employed to construct complex organic compounds, facilitating the advancement of chemical research and the discovery of novel materials.
Used in Research and Development:
5-Bromo-2-fluorobenzylamine hydrochloride is also used in research and development settings to explore its chemical properties and potential applications. Its ability to undergo various reactions makes it a valuable tool for scientists working on innovative organic and pharmaceutical chemistry projects.
Safety Considerations:
It is crucial to handle 5-Bromo-2-fluorobenzylamine hydrochloride with care and adhere to all safety protocols when working with it in a laboratory environment to ensure the safety of personnel and the integrity of the experiments.

Upstream product

• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 146328-85-0 5-bromo-2-fluoro-benzoic acid 
• 67-56-1 methanol 
• 99725-12-9 4-bromo-2-(bromomethyl)-1-fluorobenzene 
• 51437-00-4 5-bromo-2-fluorotoluene 
• 99748-26-2 2-(acetoxymethyl)-4-bromo-1-fluorobenzene 

Downstream Products

• 481681-02-1 (4-fluoro-3-(hydroxymethyl)phenyl)boronic acid 
• 99725-12-9 4-bromo-2-(bromomethyl)-1-fluorobenzene 
• 530141-44-7 2-[(5-bromo-2-fluorophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione 
• 1544739-35-6 (5aR,6S,6aS)-3-((2’,6’-dimethyl-4’-((3-methyloxetan-3-yl)methoxy)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544739-36-7 (5aR,6S,6aS)-ethyl 3-((2’,6’-dimethyl-4’-((3-methyloxetan-3-yl)methoxy)-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1352733-99-3 [2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanol 
• 1544741-12-9 (5aR,6S,6aS)-3-((2-fluoro-5-(2-methyl-6-(3-((methylsulfonyl)methyl)azetidin-1-yl)pyridin-3-yl)benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544741-16-3 (5aR,6S,6aS)-ethyl 3-((2-fluoro-5-(2-methyl-6-(3-((methylsulfonyl)methyl)azetidin-1-yl)pyridin-3-yl)benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544740-79-5 4-[2-fluoro-5-(2-trifluoromethyl-phenoxy)-benzyloxy]-1,1a,6,6a-tetrahydro-3-aza-cyclopropa[a]indene-1-carboxylic acid 
• 1544740-80-8 4-[2-fluoro-5-(2-trifluoromethyl-phenoxy)-benzyloxy]-1,1a,6,6a-tetrahydro-3-aza-cyclopropa[a]indene-1-carboxylic acid ethyl ester 
• 1544740-50-2 (5aR,6S,6aS)-3-((4-fluoro-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544741-33-4 (5aR,6S,6aS)-ethyl 3-((4-fluoro-2’,6’-dimethyl-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544740-44-4 (5aR,6S,6aS)-3-((2-fluoro-5-(6-((4-hydroxy-4-methylpentyl)oxy)-4-(trifluoromethyl)pyridin-3-yl) benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544740-48-8 (5aR,6S,6aS)-ethyl 3-((2-fluoro-5-(6-((4-hydroxy-4-methylpentyl)oxy)-4-(trifluoromethyl)pyridin-3-yl) benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 

Relevant academic research and scientific papers

PHOSPHONATE CONJUGATES AND USES THEREOF

Phosphonate conjugates, preferably, bisphosphonate conjugates; methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.

BICYCLIC PROLINE COMPOUNDS

The invention is concerned with the compounds of formula (I) and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

NRF2 REGULATORS

Provided are aryl analogs，pharmaceutical compositions containing them and their use as NRF2 regulators.

1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS

The invention is concerned with the compounds of formula I and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS

The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS

The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula I are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

N3-SUBSTITUTED IMINOPYRIMIDINONES AS RENIN INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides provides certain N3-substituted iminopyrimidinones of Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoiso

Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543

Here, a series of C-glucosides with azulene rings in the aglycon moiety was synthesized and the inhibitory activities toward hSGLT1 and hSGLT2 were evaluated. Starting from the azulene derivative 7 which had relatively good SGLT2 inhibitory activity, comp

OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF

The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

THIAZOLE DERIVATIVES AS SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.