938-50-1Relevant academic research and scientific papers
PROCESS FOR PREPARING 2,6-DIALKYLPHENYLACETIC ACIDS
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, (2022/01/04)
The invention relates to a multi-stage process for preparing 2,6-dialkylphenylacetic acids of the general formula (I) by reacting 2,6-dialkylbromobenzenes with (1) magnesium, (2) a formamide, (3) an acid, (4) hydrogenation of the benzaldehyde obtained, (5
Ligand-accelerated ortho -C-H alkylation of arylcarboxylic acids using alkyl boron reagents
Thuy-Boun, Peter S.,Villa, Giorgio,Dang, Devin,Richardson, Paul,Su, Shun,Yu, Jin-Quan
supporting information, p. 17508 - 17513 (2014/01/06)
A protocol for the Pd(II)-catalyzed ortho-C-H alkylation of phenylacetic and benzoic acids using alkylboron reagents is disclosed. Monoprotected amino acid ligands (MPAA) were found to significantly promote reactivity. Both potassium alkyltrifluoroborates and alkylboronic acids were compatible coupling partners. The possibility of a radical alkyl transfer to Pd(II) was also investigated.
Method for Producing (2,4-Dimethylbiphenyl-3-yl)Acetic Acids, the Esters Thereof and Intermediate Compounds
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, (2012/05/20)
The present invention relates to a novel process for preparing substituted and unsubstituted (2,4-dimethylbiphenyl-3-yl)acetic acids and their esters of the formula (I) using homogeneous and heterogeneous palladium catalysts, and also the intermediates 4-tert-butyl-2,6-dimethylphenylacetic acid and 4-tert-butyl-2,6-dimethylmandelic acid, and to processes for their preparation.
KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
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Page/Page column 84, (2011/10/31)
The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are a pharmaceutical composition and method of use thereof.
Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
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Page/Page column 18, (2009/07/03)
Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
Facile Cleavage of Bibenzyls by Cs-K-Na Alloy Leading to the Formation of Benzyl Carbanions
Sengupta, Dibyendu,Grovenstein, E.
, p. 185 - 186 (2007/10/02)
Facile cleavage of twelve substituted bibenzyls (1-12) with Cs-K-Na alloy at -75 deg C leading to the formation of benzyl carbanions has been studied.
Carbanions. 23. Cleavage of 1,2-Diphenylethane and Derivatives by Cs-K-Na Alloy. Cometitive Rates of Bond Scission
Grovenstein, Erling,Bhatti, Amjad M.,Quest, Dean E.,Sengupta, Dibyendu,VanDerveer, Don
, p. 6290 - 6299 (2007/10/02)
The following hydrocarbons are cleaved at a C-C bond to allylic and or/benzylic cesium compounds within 2 h by Cs-K-Na alloy in THF at -75 deg C: meso-2,3-diphenylbutane, 2,3-dimethyl-2,3-diphenylbutane, 1,2,2-triphenylpropane, 4-phenyl-1-butene, bibenzyl, and eight o-,m-, or p-methyl derivatives of bibenzyl.Under the same conditions 2-methyl- and 3-methyl-4-phenyl-1-butene were partially cleaved, 4,4'-dimethylbibenzyl was only slightly cleaved, and 9,10-dihydrophenanthrene was not detectably cleaved, while 10,11-dihydro-5H-dibenzocycloheptene underwent alternative C-H bond cleavage.Under the present reaction conditions 4,4'-dimethylbibenzyl and 9,10-dihydrophenanthrene were converted largely to dianions.It is suggested that all of the compounds undergoing cleavage are converted to dianions prior to cleavage.From competitive experiments the rates of reductive cleavage of most of these hydrocarbons relative to bibenzyl have been measured at -75 deg C.The relative rates of cleavage of m- and p-methylderivatives of bibenzyl may be correlated with the relative equilibrium acidities of toluene, m-xylene, and p-xylene in a modified Hammett relationship.Cleavages of benzylic C-C bonds are believed to occur by way of a preferred transition-state geometry,7, which permits the ?* orbital of the bond undergoing cleavage to interact with the HOMO's of both aromatic rings.Compounds that cannot attain this transition-state geometry are cleaved slowly if at all.The variable effect upon reaction rate of methyl groups near the bond undergoing cleavage are discussed in terms of ground-state and transition-state atrain, solvation, and polarizability of methyl groups.According to labeling experiments (o-methylbenzyl)cesium undergoes ready intramolecular sigmatropic migration of hydrogen from the methyl group to the methylene group when warmed from -75 deg C to near room temperature.
