938433-11-5Relevant academic research and scientific papers
Glycerol acyl-transfer kinetics of a circular permutated Candida antarctica lipase B
Laszlo, Joseph A.,Yu, Ying,Lutz, Stefan,Compton, David L.
, p. 175 - 180 (2011)
Triacylglycerols containing a high abundance of unusual fatty acids, such as γ-linolenic acid, or novel arylaliphatic acids, such as ferulic acid, are useful in pharmaceutical and cosmeceutical applications. Candida antarctica lipase B (CALB) is quite often used for non-aqueous synthesis, although the wild-type enzyme can be rather slow with bulky and sterically hindered acyl donor substrates. The catalytic performance of a circularly permutated variant of CALB, cp283, with various acyl donors and glycerol was examined. In comparison to wild-type CALB, butyl oleate and ethyl γ-linolenate glycerolysis rates were 2.2- and 4.0-fold greater, respectively. Cp283 showed substrate inhibition by glycerol, which was not the case with the wild-type version. With either ethyl ferulate or vinyl ferulate acyl donors, cp283 matched the performance of wild-type CALB. Changes in active site accessibility resulting from circular permutation led to increased catalytic rates for bulky fatty acid esters but did not overcome the steric hindrance or energetic limitations experienced by arylaliphatic esters.
Ferulic acid derivative and application thereof
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Paragraph 0027-0029, (2018/07/30)
The invention discloses a ferulic acid derivative and application thereof, and belongs to the field of structural modification of microorganism secondary metabolites being applied to agricultural plant protection. The ferulic acid derivative is prepared from 4-(4-hydroxy-3-methoxyphenyl)-3-butene-2-ketone, 4-hydroxy-3-methoxyl cinnamic acid vinyl ester, 3-(4-hydroxy-3-methoxyphenyl)-N-(4-methoxyphenyl)acrylamide and N-(4-fluorophenyl) -3-(4-hydroxy-3-methoxyphenyl) acrylamide. The ferulic acid derivative has the very high activity of inhibiting growing of weeds and killing and removing the weeds, has certain inhibition effects on amaranthus retroflexus, barnyard grass, crab grass, green bristlegrass, oilseed rape and the like, can be widely applied to agricultural production, is a novel active ingredient of weed killers, and has the advantages that the preparation method is simple, the synthetic raw materials are easy to obtain, and the ferulic acid derivative is safe and environmentally friendly, does not make any harm to non-target crops and the like.
COMPOUNDS FOR INHIBITING LIPID OXIDATION AND A METHOD FOR PRODUCING THE SAME
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Paragraph 0135-0136; 0143, (2017/05/03)
The present invention relates to a compound for inhibiting lipid oxidation, and a producing method thereof. The compound for inhibiting lipid oxidation is synthesized by a transesterification reaction though a vinyl reaction and a lipase-catalyzed reaction. The produced compound for inhibiting lipid oxidation has an excellent effect of inhibiting oxidation according to a total oxidation value (TOTOX) which is a combination of a P-anisidine value (P-AnV) and a peroxide value (PV) and an analysis of a thiobarbituric acid reaction substance (TBARS).COPYRIGHT KIPO 2016
Donor specificity and regioselectivity in Lipolase mediated acylations of methyl α-d-glucopyranoside by vinyl esters of phenolic acids and their analogues
Mastihubova, Maria,Mastihuba, Vladimir
supporting information, p. 5389 - 5392 (2013/09/23)
Methyl α-d-glucopyranoside as a model acceptor was acylated by several phenolic and non-phenolic vinyl esters using immobilised Lipolase. Donor specificity and regioselectivity of reaction were investigated. Conversion and rate of acylation by structurally varied donors indicates that the synthetic reactivity of Lipolase corresponds to the hydrolytic activity of feruloyl esterase type A. Lipolase exhibited remarkable regioselectivity for primary position of methyl α-d-glucopyranoside. The acylation occurred exclusively at 6-O primary position when vinyl esters of phenolic acids (hydroxybenzoates, hydroxyphenylalkanoates and hydroxycinnamates) served as acyl donors (5-77%). In addition to the major 6-O-acyl products (52-79%), 2,6-di-O-acylated derivatives were isolated from reaction mixtures (2-13%) when non-phenolic donors were used (vinyl esters of fully methoxylated derivatives of phenolic acids, along with vinyl benzoates, cinnamates or some heterocyclic analogues).
