94098-58-5

Upstream product

• 94-30-4 ethyl 4-methoxybenzoate 
• 16348-49-5 2-amino-N’-hydroxybenzimidamide 
• 2042-37-7 o-cyanobromobenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 108-91-8 cyclohexylamine 
• 75-64-9 tert-butylamine 
• 78-81-9 isobutylamine 
• 75-31-0 isopropylamine 
• 100-46-9 benzylamine 
• 33966-50-6 SEC-BUTYLAMINE 
• 153172-71-5 N-(2-cyanophenyl)-4-methoxybenzamide 
• 138642-62-3 2-Cyanophenylboronic acid 
• 4387-36-4 2-iodobenzonitrile 
• 5784-95-2 2-(4-methoxyphenyl)-1H-indole 

Downstream Products

• 94078-94-1 4-Amino-2-(4-methoxyphenyl)chinazolin-hydrochlorid 

Relevant academic research and scientific papers

Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine

Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.

Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile

4-Substituted O-benzyl benzamide oximes reacted with 2-iodobenzonitrile in the presence of 0.1 mol % of [Pd2(dba)3], 0.2 mol % of XantPhos, and 1.5 equiv of Cs2CO3 in dioxane under argon to give 2-arylquinazolin

Efficient synthesis of 2-arylquinazolin-4-amines via a copper-catalyzed diazidation and ring expansion cascade of 2-arylindoles

Copper-catalyzed synthesis of 2-arylquinazolin-4-amines from readily available 2-arylindoles and TMSN3 has been developed. The mechanism study shows that the domino reaction may involve a free radical diazidation, denitrogenation, intramolecular cyclization and ring expansion sequence.

Expeditious Synthesis of 2-Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy

A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the synthesis of 2-phenylquinazolin-4-amines from commercially available ortho-halogenated benzonitriles, aldehydes, and sodium azide. This elegant domino process involved con

One-pot synthesis of 2-arylquinazolines and tetracyclic isoindolo[1,2-a]quinazolines via cyanation followed by rearrangement of ortho-substituted 2-halo-N-arylbenzamides

The one-pot synthesis of substituted 2-arylquinazoline derivatives and tetracylic isoindolo[1,2-a]quinazoline via cyanation followed by rearrangement of ortho-substituted 2-halo-N-arylbenzamides is described. Using dimethyl sulfoxide (DMSO) as the solvent

Dawson heteropolyacid: A green, eco-friendly, and reusable catalyst for one-pot synthesis of 4-aminoquinazolines

A new multicomponent synthesis of 4-aminoquinazolines from the reaction of anthranilonitrile, acylchlorides, and ammonium acetate in the presence of catalytic amounts of Dawson-type heteropolyacids (HPAs) is reported. The catalytic performance of different forms of Dawson-type HPAs, H6 P2M18O62 (M = WVI, MoVI) and mixed addenda forms (M = CoII, CuII, NiII, MnIII) were compared and in all cases, maximum of yield was observed by using H6P2W18O62 as catalyst. The plausible mechanism was estimated. In all cases, the Dawson catalyst was easily recovered and recycled with retention of their initial structure and activity. The effects of reaction conditions have been studied and the results showed yields of reaction are good to excellent. Copyright Taylor and Francis Group, LLC.

Simple efficient synthesis of 4-aminoquinazoline via amidine of N-arylamidoxime

Preparation of 4-amino-2-aryl quinazolines by reduction of N-(2-cyanoaryl) amidoximes via amidines using SnCl2 in ethanol.

Efficient three-component synthesis of 4-aminoquinazolines

4-Aminoquinazolines were synthesized in good yields via a one-pot, three-component reaction of anthranilonitrile, acylchlorides, and ammonium acetate in the presence of catalytic amounts silica-supported Preyssler nanoparticles under refluxing conditions.

An efficient method to prepare 4-aminoquinazolines: Potential application to conformation-restricted bleomycin analogs

(Chemical Equation Presented) To enhance the iron-chelating ability of P-3A, 4-aminoquinazolines were designed as conformation-restricted bleomycin analogs. An efficient method was developed to prepare the 4-aminoquinazoline heterocyclic nucleus, which en

Microwave enhanced synthesis of 4-aminoquinazolines

Cyanoaromatic compounds react with anthranilonitrile in a domestic microwave oven affording good yields of the corresponding 4-aminoquinazolines in a very short irradiation time. (C) 2000 Elsevier Science Ltd.