94242-82-7

Upstream product

• 2146-67-0 (dichloromethyl)lithium 
• 87100-28-5 pinacol benzylboronate 
• 83622-41-7 pinacol dichloromethylboronic ester 
• 6921-34-2 benzylmagnesium chloride 
• 1259299-79-0 2-(1-chloro-2-phenylvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 536-74-3 phenylacetylene 
• 159087-45-3 4,4,5,5-tetramethyl-2-phenylethynyl-[1,3,2]dioxaborolane 
• 1333-74-0 hydrogen 
• 75-09-2 dichloromethane 
• 162213-35-6 C₁₃H₂₁BO₂ 
• 1589-82-8 phenylmagnesium bromide 
• 4463-42-7 benzyl boronic acid 
• 76-09-5 2,3-dimethyl-2,3-butane diol 

Downstream Products

• 94242-83-8 2-[1-(1,1,1,3,3,3-hexamethyl-disilazan-2-yl)-2-phenyl-ethyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 97571-08-9 2-(3,3-dimethyl-1-phenylbutan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant academic research and scientific papers

Ni-Catalyzed Reductive Allylation of α-Chloroboronates to Access Homoallylic Boronates

The transition-metal-catalyzed allylation reaction is an efficient strategy for the construction of new carbon-carbon bonds alongside allyl or homoallylic functionalization. Herein we describe a Ni-catalyzed reductive allylation of α-chloroboronates to efficiently render the corresponding homoallylic boronates, which could be readily converted into valuable homoallylic alcohols or amines or 1,4-diboronates. This reaction features a broad substrate scope with good functional group compatibility that is complementary to the existing methods for the preparation of homoallylic boronates.

Iridium-catalyzed chemoselective and enantioselective hydrogenation of (1-Chloro-1-Alkenyl) boronic esters

Persistent chlorine: Hydrogenation of borolane-substituted vinylic chlorides catalyzed by Ir-P N complexes greatly preserved the chlorine substituent on the hydrogenated product, with only 3-19 % of dechlorinated byproducts present after hydrogenation. Th

P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease

A series of peptide boronic acids containing extended, hydrophobic P1 residues was prepared to probe the shallow, hydrophobic S1 region of HCV NS3 protease. The p-trifluoromethylphenethyl P1 substituent was identified as optimal with respect to inhibitor potency for NS3 and selectivity against elastase and chymotrypsin.

An α-lithio boronic ester from an α-trimethylstannyl boronic ester

Pinacol (1-chloroethyl)boronate (1A) and lithiotrimethylstannane have yielded pinacol [1-(trimethylstannyl)ethyl]boronate (2), which with methyllithium at -100C yields pinacol 1-lithioethylboronate (3). Capture of 3 by (-haloalkyl)boronic esters results in carbon-carbon bond formation. Generation of 3 from pinacol (1-iodoethyl)boronate with tert-butyllithium is followed by rapid reaction with the remaining (1-iodoethyl)boronate.