94640-18-3

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 5-cyano-1,4,5,6-tetrahydro-4-(4-methoxyphenyl)-2-methyl-6-oxo-, ethyl ester
• CAS NO: 94640-18-3
• Molecular Formula: C17H18N2O4
• Molecular Weight: 314.341
• Mol File: 94640-18-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 5-cyano-1,4,5,6-tetrahydro-4-(4-methoxyphenyl)-2-methyl-6-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 5-cyano-1,4,5,6-tetrahydro-4-(4-methoxyphenyl)-2-methyl-6-oxo-, ethyl ester(94640-18-3)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 5-cyano-1,4,5,6-tetrahydro-4-(4-methoxyphenyl)-2-methyl-6-oxo-, ethyl ester(94640-18-3)

Safety Data

• Hazardous Substances Data: 94640-18-3(Hazardous Substances Data)

Upstream product

• 7324-84-7 3-(4-methoxyphenyl)-2-cyanopropenamide 
• 626-34-6 ethyl aminocrotonate 
• 141-97-9 ethyl acetoacetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 107-91-5 cyanoacetic acid amide 
• 89809-76-7 ethyl 6-amino-4-(4-methoxyphenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 7324-84-7 (E)-2-cyano-3-(4-methoxyphenyl)acrylamide 
• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 

Downstream Products

• 78942-34-4 ethyl 5-cyano-4-(4-methoxyphenyl)-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 

Relevant articles and documents

Chem-grafted Zn-SSA as an Efficient Heterogeneous Catalyst to Synthesize 2-Pyridinones

Abstract: Chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be a high efficient heterogeneous catalyst to solve this problem. Under Zn–SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production. Graphical Abstract: Improving chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be efficient heterogeneous catalyst to solve this problem. Under Zn-SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production.[Figure not available: see fulltext.]

Synthesis of 3,4-dihydropyridin-2-one derivatives in convergent mode applying bio catalyst vitamin B1 and polymer supported catalyst PEG-SO3H from two different sets of building blocks

Two highly efficient, green protocols have been developed for the synthesis of 3,4-dihydropyridin-2-one derivatives from different starting materials exploring two reaction specific catalysts, vitamin B1 (VB 1), and PEG-SO3/sub

REACTIONS OF SIX-MEMBERED HETEROCYCLIC β-ENAMINONITRILES WITH ELECTROPHILIC REAGENTS

The nitriles I reacted with acetylacetone and with ethyl acetoacetate to afford 2-amino-3-cyano-4H-pyran derivatives.They reacted further to yield pyranopyridine derivatives.The reaction of V with acetylacetone afforded the pyridinethione VIII.This afford