94670-39-0

Basic information

• Product Name: Benzamide, 4-chloro-N-formyl-
• CAS NO: 94670-39-0
• Molecular Formula: C8H6ClNO2
• Molecular Weight: 183.594
• Mol File: 94670-39-0.mol

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-chloro-N-formyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-chloro-N-formyl-(94670-39-0)
• EPA Substance Registry System: Benzamide, 4-chloro-N-formyl-(94670-39-0)

Safety Data

• Hazardous Substances Data: 94670-39-0(Hazardous Substances Data)

Usage

Uses

Used in Drug Development:
Benzamide, 4-chloro-N-formylis used as a chemical intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with different properties and therapeutic effects compared to existing compounds.
Used in Scientific Research:
Benzamide, 4-chloro-N-formylis used as a research reagent in various scientific experiments. Its unique properties make it a valuable tool for studying the structure-activity relationship in pharmaceutical compounds and for investigating the mechanisms of drug action.
Used in Medicinal Chemistry:
Benzamide, 4-chloro-N-formylis used in medicinal chemistry to explore its potential as a therapeutic agent. Its unique structure may provide new insights into the design of drugs with improved efficacy and selectivity for specific targets.

Upstream product

• 13450-77-6 4-chlorohippuric acid 
• 619-56-7 4-chlorobenzamide 
• 124-38-9 carbon dioxide 
• 74-11-3 para-chlorobenzoic acid 
• 6873-44-5 p-chloro-N-methylbenzamide 
• 68-12-2 N,N-dimethyl-formamide 
• 3473-63-0 formamidine acetic acid 
• 122-01-0 4-chloro-benzoyl chloride 
• 103369-14-8 N-(4-chlorobenzoyl)-2-hydroxyglycine 
• 64-19-7 acetic acid 

Relevant articles and documents

An NHC-Stabilised Phosphinidene for Catalytic Formylation: A DFT-Guided Approach

In recent years, the applications of low-valent main group compounds have gained momentum in the field of catalysis. Owing to the accessibility of two lone pairs of electrons, NHC-stabilised phosphinidenes have been found to be excellent Lewis bases; however, they cannot yet be used as catalysts. Herein, an NHC-stabilised phosphinidene, 1,3-dimethyl-2-(phenylphosphanylidene)-2,3-dihydro-1H imidazole (1), for the activation of CO2 is reported.A closer inspection of the CO2 activation process by DFT calculations along with intrinsic bond orbital analysis shows that phosphinidene is associated with phenylsilane through a noncovalent π-π interaction between two phenyl rings which activates the Si?H bond facilitating hydride transfer to the CO2 molecule. Detailed DFT studies along with spectroscopic experiments were combined to understand the mechanism of CO2 activation and its catalytic reductive functionalisation leading to the formylation of a range of chemically inert primary amides under mild reaction conditions.

Designing a Cr-catalyst bearing redox non-innocent phenalenyl-based ligand towards hydrosilylative CO2functionalization

Herein, we report the synthesis of a Cr(iii)-complex bearing a redox non-innocent phenalenyl-based ligand and its use as a catalyst for SET mediated hydrosilylative reduction of carbon dioxide towards formylation of primary amides under mild conditions. A

Metal-Free Catalytic Formylation of Amides Using CO2 under Ambient Conditions

This study reports the metal-free formylation of amides using carbon dioxide under ambient conditions. An abnormal N-heterocyclic carbene (aNHC) acts as an efficient catalyst for the formylation of amides in the presence of hydrosilane at room temperature

Visible-Light-Driven Oxidation of N -Alkylamides to Imides Using Oxone/H 2 O and Catalytic KBr

Imides are prepared conveniently by visible-light-driven oxidations of various N -alkylamides under mild conditions. The majority of the reactions proceed efficiently by using Oxone as the oxidant in the presence of a catalytic amount of KBr in H 2 O/CH 2 Cl 2 under irradiation by an 8 W white LED at room temperature. Experimental studies suggest that an imine, obtained from the substrate amide via a radical process, is the key intermediate.

Otherwise inert reaction of sulfonamides/carboxamides with formamides via proton transfer-enhanced reactivity

NBS-mediated addition-elimination reaction of sulfonamides/carboxamides and formamides afforded N-sulfonylamidines and N-formylarylamides, respectively, depending on the different mechanism of elimination. Hydrogen bond-induced proton transfer leads to en

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Two syntheses of N-formylmaleamic acid and some related N-formylamides are described which take place under very mild conditions.

A facile synthesis of N-formylbenzamides by oxidative decarboxylation of N-aroylglycine induced by Ag+/S2O82-

A facile method is described for the synthesis of N-formylbenzamides by oxidative decarboxylation of N-aroylglycine using catalytic silver(I) and 2 equivalents of ammonium persulfate as an oxidant in a biphasic system (CHCl 3/water).

The Oxidative Decarboxylation of N-Aroylglycines to N-(Aacetoxymethyl)benzamides and N-Formylbenzamides with Lead(IV) Acetate

Treatment of N-aroylglycines that do not bear a strong electron-withdrawing substituents with lead(IV) acetate in acetic acid/acetic anhydride mixtures at 60-100 deg C rapidly gives the corresponding N-(acetoxymethyl)benzamides and N-formylbenzamides in m