95139-63-2

Upstream product

• 51490-05-2 1,2-bis(4-chlorophenyl)ethanone 
• 70-11-1 α-bromoacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 90-97-1 4,4'-dichlorobenzophenone 
• 86147-03-7 α-ethenyl-α-(4-chlorophenyl)-4-chlorobenzenemethanol 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 100-52-7 benzaldehyde 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 191861-13-9 2,3-di-(p-chlorophenyl)-5-phenylthiophene 

Relevant academic research and scientific papers

N-Heterocyclic Carbene Acyl Anion Organocatalysis by Ball-Milling

The ability to conduct N-heterocyclic carbene-catalysed acyl anion chemistry under ball-milling conditions is reported for the first time. This process has been exemplified through applications to intermolecular-benzoin, intramolecular-benzoin, intermolecular-Stetter and intramolecular-Stetter reactions including asymmetric examples and demonstrates that this mode of mechanistically complex organocatalytic reaction can operate under solvent-minimised conditions.

Oxidative acylation of α,α-diarylallylic alcohols: Synthesis of 1,2,4-triarylbutane-1,4-diones

A metal-free mediated oxidative acylation of α,α-diarylallylic alcohols with simple aromatic aldehydes for the synthesis of 1,2,4-triphenylbutane-1,4-diones is presented. In the presence of TBPB (tert-butyl peroxybenzoate), desired products were obtained in good to excellent yields for 28 examples. This protocol features high regioselectivity, wide functional group tolerance and atom economy.

1,4-dicarbonyl compound and preparation method thereof

The invention provides a 1,4-dicarbonyl compound and a preparation method thereof. The preparation method comprises the following steps: (1) adding alpha,alpha-diaryl allyl alcohol, aromatic formaldehyde, TBPB (tert-butyl peroxybenzoate) and methylbenzene into a Schlenk tube, and reacting for 20 to 28 hours at the temperature of 100 to 140 DEG C under an air condition so as to obtain a reaction product; and (2) washing the reaction product in the step (1) with a saturated NaCl solution, then carrying out extraction by using ethyl acetate, carrying out reduced pressure distillation to remove a solvent to obtain a crude product, carrying out thin-layer chromatography separation on the crude product by using petroleum ether and ethyl acetate as developers so as to obtain the 1,4-dicarbonyl compound. The innovation point lies in that addition rearrangement acylation on olefinic bonds is directly realized through a C-H bond direct functionalization method in allyl alcohol creatively, so that a synthetic method for synthesizing the 1,4-dicarbonyl compound is created.

UV light-mediated difunctionalization of alkenes through aroyl radical addition/1,4-/1,2-Aryl shift cascade reactions

UV light-mediated difunctionalization of alkenes through an aroyl radical addition/1,4-/1,2-aryl shift has been described. The resulted aroyl radical from a photocleavage reaction added to acrylamide compounds followed by cyclization led to the formation of oxindoles, whereas the addition to cinnamic amides aroused a unique 1,4-aryl shift reaction. Furthermore, the difunctionalization of alkenes of prop-2-en-1-ols was also achieved through aroyl radical addition and a sequential 1,2-aryl shift cascade reaction.

Samarium-promoted michael addition between aroyl chlorides and chalcones

A novel Michael addition type reaction between aroyl chlorides and chalcones was realized in the presence of samarium metal when N,N-dimethylformamide was used as a solvent. A variety of 1,4-diketones were thereby synthesized in moderate to good yields. T

Synthesis of 2,3,5-triaryl-4-trifluoromethyl thiophenes

Triaryl-β-trifluoromethyl thiophenes are synthesized from 1,3-dithiolium-4-olates and various substituted 1-aryl-3,3,3-trifluoro-1-propynes. The spectroscopic characteristics of the products and the regioselectivity of the reaction are discussed.