95161-87-8

Upstream product

• 64-17-5 ethanol 
• 854682-22-7 3-(4-benzyloxy-phenyl)-2-bromo-1-(2-hydroxy-phenyl)-3-methoxy-propan-1-one 
• 151-50-8 potassium cyanide 
• 4143-63-9 4'-hydroxyflavone 
• 100-39-0 benzyl bromide 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 200411-98-9 3-(4-benzyloxyphenyl)-1-(2-hydroxylphenyl)-prop-2-en-1-one 
• 897599-06-3 (1H-benzo[d][1,2,3]triazol-1-yl)[4-(benzyloxy)phenyl]methanone 
• 118-93-4 o-hydroxyacetophenone 
• 32122-11-5 4-benzyloxy-benzoic acid methyl ester 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 1486-51-7 p-(benzyloxy)benzoic acid 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 4143-63-9 4'-hydroxyflavone 
• 14919-49-4 3-hydroxy-2-(4-hydroxy-phenyl)-chromen-4-one 
• 102468-65-5 2-(4-(benzyloxy)phenyl)-3-hydroxy-4H-chromen-4-one 

Relevant academic research and scientific papers

Silica-gel-supported Ce(SO4)2·4H2O-mediated cyclization of 2′-amino and 2′-hydroxychalcones under solvent-free conditions

A simple, efficient, and environmentally friendly approach for the synthesis of flavones, aza-flavones, and aza-flavanones from corresponding 2′-hydroxy or 2′-aminochalcones has been developed. The reactions are successfully conducted in presence of silica-gel-supported Ce(SO4)2·4H2O under solvent-free conditions.

Synthetic studies of fisetin, myricetin and nobiletin analogs and related probe molecules

We synthesized a series of analogs of fisetin, myricetin and nobiletin, as well as related fluorescein- and biotin-based flavone-probe molecules, on a suitable scale for biological and structure-activity relationship studies.

FeCl3 catalyzed dehydrative cyclisation of 1, 3 - (diaryl diketones) to flavones

FeCl3 in catalytic amount effects smooth conversion of substituted 1- (2-hydroxy phenyl) - 3 - phenyl - 1, 3 - propanediones to the corresponding flavones in high yields.

Synthesis, spectroscopic, luminescence, electrochemical and antibacterial studies of ruthenium(II) polypyridyl complexes containing 3-hydroxyflavones as co-ligand

Some mononuclear Ru(II) polypyridyl (2,2′-bipyridyl/1,10 -phenanthroline) complexes containing 3-hydroxy-4′substituted flavones (L2H and L4H) as co-ligands have been synthesised and characterised on the basis of their elemental analyses, FAB mass and spectral (IR, UV/visible, 1H NMR, and 1H-1H COSY NMR) data. Luminescence, electrochemical and antibacterial properties of the ligands and their RU(II) complexes have also been discussed.

Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: Structure-activity relationships

Although some progress has been reported on structure-activity relationships (SARs) for inhibitors of mammalian P-glycoprotein MDR efflux pumps, there is almost nothing in the literature regarding SARs for inhibitors of any bacterial efflux pump. Indeed, only a few of these have been described. Our discovery of a potent naturally occurring flavonolignan inhibitor of the NorA MDR pump of Staphylococcus aureus provided a structural foundation upon which SARs could be assessed via synthetic analogues. Several flavonolignans were prepared which proved to have greater potency than the natural isolate, 5′-methoxyhydnocarpin-D, while others showed decreased potency. Surprisingly, some simple alkylated flavones also were quite active MDR pump inhibitors. Variability of activity among the compounds tested was sufficient so that at least some SARs could be postulated and compared with those known for P-glycoprotein.