95166-87-3Relevant academic research and scientific papers
PPh3-catalyzed Mannich reaction: A facile one-pot synthesis of β-amino carbonyl compounds under solvent-free conditions at room temperature
Abedini-Torghabeh, Javad,Eshghi, Hossein,Bakavoli, Mehdi,Rahimizadeh, Mohammad
, p. 3649 - 3658 (2015)
PPh3 was used as an efficient catalyst for the one-pot three-component Mannich reactions of acetophenone with different aromatic amines and aromatic aldehydes under solvent-free conditions at room temperature. This method provides a novel and improved method for preparing β-amino carbonyl compounds in the absence of acidic catalyst in excellent yield. Little catalyst loading, easy accessibility of the catalyst, mild conditions, and simple work-up procedure are the main features of this protocol.
Sulfonic acid supported on magnetic nanoparticle as an eco-friendly, durable and robust catalyst for the synthesis of β-amino carbonyl compounds through solvent free Mannich reaction
Kabiri Esfahani, Farhad,Zareyee, Daryoush,Shokuhi Rad, Ali,Taher-Bahrami, Sima
, (2017/09/30)
A simple, efficient and environmentally benign solid acid catalyst was prepared by anchoring a propyl sulfonic acid on the surface of silica-coated magnetic nanoparticles by low cost precursors. The catalyst has been then engaged in the efficient β-amino carbonyl compounds production via three component Mannich reaction under solvent free reaction condition at room temperature. After the completing the reaction, the catalyst was readily separated by external magnet and reused for 10 successive rounds of reaction, without any significant loss in catalytic efficiency. The solid acidic system presented reusable strategy for the efficient synthesis of β-amino carbonyl compounds, simplicity in operation, and green aspects by avoiding toxic conventional catalysts under solvent-free condition.
One-pot three-component Mannich reaction in water catalyzed by eco-friendly, hydrophobic and recyclable sulfonic acid based nanosilica (SBA-15-Ph-PrSO3H)
Zareyee, Daryoush,Alizadeh, Hamidreza
, p. 37941 - 37946 (2014/11/07)
A mild, effective and green method for the Mannich reaction of aromatic aldehydes, aromatic amines and ketones has been accomplished in good to excellent yields using hydrophobic SBA-15-Ph-PrSO3H in water at room temperature. This new method consistently has the advantages of excellent yields, short reaction times, and non-toxic nature and reusability of the catalyst. Additionally, utilization of water as a green solvent, simple reaction conditions, isolation, and purification make this manipulation interesting from an environmental perspective. the Partner Organisations 2014.
One-pot three-component Mannich reaction in water catalyzed by eco-friendly, hydrophobic and recyclable sulfonic acid based nanosilica (SBA-15-Ph-PrSO3H)
Zareyee, Daryoush,Alizadeh, Hamidreza
, p. 37941 - 37946 (2015/02/19)
A mild, effective and green method for the Mannich reaction of aromatic aldehydes, aromatic amines and ketones has been accomplished in good to excellent yields using hydrophobic SBA-15-Ph-PrSO3H in water at room temperature. This new method consistently has the advantages of excellent yields, short reaction times, and non-toxic nature and reusability of the catalyst. Additionally, utilization of water as a green solvent, simple reaction conditions, isolation, and purification make this manipulation interesting from an environmental perspective. This journal is
The Mannich reaction between aromatic ketones, aromatic aldehydes and aromatic amines
Lin,Huangshu,Junhua,Xiujuan
, p. 717 - 718 (2007/10/02)
The acid-catalyzed Mannich reaction of acetophenones with benzaldehyde derivatives and aromatic amines gives 1,3-diaryl-3-(arylamino)propanones in high yield.
