Research on Chemical Intermediates p. 3649 - 3658 (2015)
Update date:2022-08-03
Topics:
Abedini-Torghabeh, Javad
Eshghi, Hossein
Bakavoli, Mehdi
Rahimizadeh, Mohammad
PPh3 was used as an efficient catalyst for the one-pot three-component Mannich reactions of acetophenone with different aromatic amines and aromatic aldehydes under solvent-free conditions at room temperature. This method provides a novel and improved method for preparing β-amino carbonyl compounds in the absence of acidic catalyst in excellent yield. Little catalyst loading, easy accessibility of the catalyst, mild conditions, and simple work-up procedure are the main features of this protocol.
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