95319-30-5Relevant academic research and scientific papers
Br?nsted Acid-Initiated Formal [1,3]-Rearrangement Dictated by β-Substituted Ene-Aldimines
Jongwohan, Chanantida,Honda, Yasushi,Suzuki, Toshiyasu,Fujinami, Takeshi,Adachi, Kiyohiro,Momiyama, Norie
supporting information, p. 4991 - 4995 (2019/07/03)
The rearrangement of ene-aldimines is a useful reaction for affording homoallylic amines. Despite their utilities in synthetic chemistry, the rearrangement for accessing homoallylic amines substituted at the 2-position remains elusive. In this study, the
Palladium(II)-Catalyzed Regioselective syn-Hydroarylation of Disubstituted Alkynes Using a Removable Directing Group
Liu, Zhen,Derosa, Joseph,Engle, Keary M.
supporting information, p. 13076 - 13081 (2016/10/13)
A palladium(II)-catalyzed regioselective syn-hydroarylation reaction of homopropargyl amines has been developed, wherein selectivity is controlled by a cleavable bidentate directing group. Under the optimized reaction conditions, both dialkyl and alkylaryl alkyne substrates were found to undergo hydroarylation with high selectivity. The products of this reaction contain a 4,4-disubstituted homoallylic amine motif that is commonly seen in drug molecules and other bioactive compounds.
Br?nsted acid TfOH-mediated reactions of methylenecyclopropanes with nitriles
Huang, Jin-Wen,Shi, Min
, p. 2343 - 2346 (2007/10/03)
In the presence of Br?nsted acid TfOH, methylenecyclopropanes react with nitriles to give [3+2] cycloaddition products in good to high yields along with Ritter reaction products. In many cases, [3+2] cycloaddition products are obtained as the major produc
N-LITHIO-N-(2-LITHIOETHYL)- AND N-LITHIO-N-(3-LITHIOPROPYL)-BENZAMIDE: DIRECT PREPARATION AND SYNTHETIC APPLICATIONS OF 2-LITHIOETHYL- AND 3-LITHIOPROPYL-AMINE EQUIVALENTS
Barluenga, Jose,Foubelo, Francisco,Fananas, Francisco J.,Yus, Miguel
, p. 2183 - 2192 (2007/10/02)
The successive reaction of 2-chloroethyl and 3-chloropropyl-benzamide with n-butyl-lithium and lithium naphthalenide at temperatures ranging between -78 and -50 deg C leads to N-lithio-N-(2-lithioethyl)- and N-lithio-N-(3-lithiopropyl)benzamide , which by treatment with different electrophiles (H2O, D2O, Me2S2, CO2, PriCHO, PhCHO, Me2CO, Ph2CO, and O2) yields the expected functionalized benzamides .The acidic and basic hydrolysis of compounds (10) and (11) gives different results depending on the structure of the substrate and the reaction conditions.
