95384-58-0

Basic information

• Product Name: N-(2-hydroxyphenyl)-2-phenylacetamide
• Synonyms: N-(2-hydroxyphenyl)-2-phenylacetamide
• CAS NO: 95384-58-0
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.25852
• Mol File: 95384-58-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-hydroxyphenyl)-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxyphenyl)-2-phenylacetamide(95384-58-0)
• EPA Substance Registry System: N-(2-hydroxyphenyl)-2-phenylacetamide(95384-58-0)

Safety Data

• Hazardous Substances Data: 95384-58-0(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 95-55-6 2-amino-phenol 
• 103-82-2 phenylacetic acid 
• 103-83-3 N,N'-dimethylbenzylamine 
• 4846-21-3 O-phenylhydroxylamine 
• 64908-64-1 2-phenoxyisoindol-1,3-dione 
• 98-80-6 phenylboronic acid 
• 260783-80-0 N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate 
• 201230-82-2 carbon monoxide 
• 854880-13-0 1-(2-phenyl-acetylamino)-2-valeryloxy-benzene 
• 1001845-90-4 1-benzoyloxy-2-(2-phenyl-acetylamino)-benzene 
• 860744-33-8 1-chloroacetoxy-2-(2-phenyl-acetylamino)-benzene 
• 858446-05-6 1-(2-phenyl-acetylamino)-2-propionyloxy-benzene 
• 692767-36-5 1-acetoxy-2-(2-phenyl-acetylamino)-benzene 

Downstream Products

• 854880-13-0 1-(2-phenyl-acetylamino)-2-valeryloxy-benzene 
• 28458-93-7 benzo[d]oxazol-2-yl(phenyl)methanone 
• 132283-16-0 Naphthalene-1-carboxylic acid 2-phenylacetylamino-phenyl ester 
• 860744-33-8 1-chloroacetoxy-2-(2-phenyl-acetylamino)-benzene 

Relevant articles and documents

Visible light-promoted copper catalyzed regioselective acetamidation of terminal alkynes by arylamines

Herein, we describe a copper photoredox catalyzed synthesis of acetamide via regioselective C-N coupling of arylamines with terminal alkynes using molecular oxygen (O2) as an oxidant at room temperature under visible light irradiation (47 examples). Unique simultaneous formation of both amide and ester functionalities occurs via intramolecular cyclization in a single-step reaction in the case of anthranilic acids using inexpensive copper as a catalyst and eco-friendly O2 as an oxidant and reagent. Different substrates undergo different reaction pathways to generate similar acetamide products, as evidenced by 18O2 labelling experiments. The current protocol was also applied for the rapid, few step preparation of biologically active inhibitors (BACE-1 and PDE4). This process can be readily scaled up to a gram scale, and calculations of green metrics suggest the economic feasibility and eco-friendly nature of the current photoredox approach.

Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C-N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.

Novel green acylamide synthesis method through quaternary ammonium salt C-N bond fracture

The invention provides a novel green acylamide synthesis method through quaternary ammonium salt C-N bond fracture. The structure of the compound is expressed by methods such as H NMR, C, NMR and HRMS and is confirmed. A series of phenmethyl quaternary ammonium salts and aminated compounds are used; under the catalysis effect of PdCl2(dppf), PPh3 is used as a ligand, Na2CO3 is used as the alkali, and corresponding amide compounds are generated in the 100-DEG C CO atmosphere in a pHMe/DMSO mixed solvent. The method has the advantages that the efficiency is high; the toxicity is low; the conditions are mild; the application range of the substrate is wide; the yield is high; the product purity is high; the separation is convenient; the method can be applicable to large-scale preparation; the application prospects are wide.