95478-18-5Relevant academic research and scientific papers
Copper-catalyzed synthesis of N-aryl acridones from 2-amino benzophenones and aryl boronic acids via sequential double oxidative C–N coupling
He, Yang,Xu, Liang,Zhang, Jinli,Wei, Yu
, (2019/12/27)
Pot-economic synthesis of N-aryl acridones was performed with 2-aminobenzophenones and aryl boronic acids as starting materials. Cu-catalyzed chelation-assisted oxidative C–N cross-coupling reactions were well merged with the following intra-molecular oxidative dehydrogenative C–H amination reactions under an air atmosphere. The use of reagent capsules can further resolve the compatibility problem of reagents and simplify the operational process, providing a more straightforward access to the target products.
Synthesis of Acridones by Palladium-Catalyzed Buchwald-Hartwig Amination
Janke, Julia,Villinger, Alexander,Ehlers, Peter,Langer, Peter
, p. 817 - 820 (2019/04/25)
The Buchwald-Hartwig amination allows an efficient and convenient synthesis of biologically and pharmaceutically important acridones by formation of a six-membered ring. With the described method, a number of derivatives have been synthesized in up to 95% yield by using a variety of anilines as well as benzylic and aliphatic amines.
Copper-catalyzed intramolecular direct amination of sp2 C-H bonds for the synthesis of N-aryl acridones
Zhou, Wang,Liu, Yong,Yang, Youqing,Deng, Guo-Jun
supporting information, p. 10678 - 10680 (2012/11/07)
A copper-catalyzed approach for the synthesis of N-aryl acridones via sp2 C-H bond amination using air as oxidant under neutral conditions is disclosed. This reaction not only provides a complementary method for synthesizing medicinally important acridones, but also offers a new strategy for sp2 C-H bond amination.
