32157-73-6

Upstream product

• 100-52-7 benzaldehyde 
• 937-20-2 p-chlorophenacyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 532-27-4 1-chloroacetophenone 
• 22966-22-9 (E)-1-(4-chlorophenyl)-3-phenyl-2-propen-1-one 
• 956-02-5 4'-chlorochalcone 
• 99-91-2 para-chloroacetophenone 
• 100-42-5 styrene 
• 14531-55-6 3,5-dimethyl-4-nitro-1H-pyrazole 
• 32157-73-6 1-(p-chlorophenyl)-2,3-epoxy-3-phenylpropan-1-one 
• 124-38-9 carbon dioxide 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 67295-28-7 1-(4-chloro-phenyl)-2-hydroxy-3-morpholin-4-yl-3-phenyl-propan-1-one 
• 76283-66-4 1-(4-Chloro-phenyl)-2-hydroxy-3-phenyl-3-thiocyanato-propan-1-one 
• 110220-78-5 2-(4-chloro-phenyl)-2-hydroxy-3-phenyl-propionic acid 
• 127634-32-6 erythro-4'-Chlor-chalkonbromhydrin 
• 1889-71-0 4'-chloro-2-phenylacetophenone 
• 59074-25-8 1-(4-chlorophenyl)-2-phenylprop-2-en-1-one 
• 32157-73-6 trans-(2R,3S)-2,3-epoxy-3-phenyl-1-(4-chlorophenyl)propan-1-one 
• 54458-32-1 1-(4-chlorophenyl)-3-phenylpropane-1,2,3-trione 
• 132455-54-0 4-Chloro-benzoic acid formyloxy-phenyl-methyl ester 

Relevant academic research and scientific papers

A high-yielding protocol for the synthesis of 4,5-diarylpyrimidin-2-amine derivatives from chalcones

A novel, high yielding and versatile protocol was achieved for the synthesis of 4,5-diaryl-2-pyrimidinamine derivatives from chalcones. The synthesis was accomplished by converting the chalcones into 3-chloro-2,3-diaryl-2-propen-1-ones followed by subsequent reaction with amidine derivatives.

Asymmetric Epoxidation of Enones Promoted by Dinuclear Magnesium Catalyst

Asymmetric synthesis with cheaper and non-toxic alkaline earth metal catalysts is becoming an important and sustainable alternative to conventional catalytic methodologies mostly relying on precious metals. In spite of some sustainable methods for enantioselective epoxidation of enones, the development of a well-defined and efficient catalyst based on magnesium complexes for these reactions is still a challenging task. In this perspective, we present the application of chiral dinuclear magnesium complexes for asymmetric epoxidation of a broad range of electron-deficient enones. We demonstrate that the in situ generated magnesium-ProPhenol complex affords enantioenriched oxiranes in high yields and with excellent enantioselectivities (up to 99% ee). Our extensive study verifies the literature data in this area and provides a step forward to better understand the factors controlling the oxygenation process. Elaborated catalyst offers mild reaction conditions and a truly wide substrate scope. (Figure presented.).

Asymmetric epoxidation of α,β-unsaturated ketones via an amine-thiourea dual activation catalysis

A simple asymmetric epoxidation method is developed to effectively synthesize chiral α-carbonyl epoxides through an amine-thiourea dual activation catalysis. In this method, TBHP, as an oxidant, determined the reaction rate, and the chiral amine-thiourea catalyst effectively controlled the stereoselectivity of the reaction, and KOH promoted deprotonation. 22 examples of α,β-unsaturated ketones with various substituent groups are smoothly converted into α-carbonyl epoxides with moderate to excellent enantiomeric excess.

Asymmetric epoxidation of α,β-unsaturated ketones catalyzed by rare-earth metal amides RE[N(SiMe3)2]3with chiral TADDOL ligands

The catalytic asymmetric epoxidation of α,β-unsaturated ketones by tert-butylhydroperoxide (TBHP) has been well established using rare-earth metal amides RE[N(SiMe3)2]3 (RE = La(1), Nd(2), Sm(3), Y(4), Yb(5)) with chiral TADDOL ligands. It was found that

Highly Enantioselective Epoxidation of α,β-Unsaturated Ketones Using Amide-Based Cinchona Alkaloids as Hybrid Phase-Transfer Catalysts

A series of 20 one chiral epoxides were obtained with excellent yields (up to 99%) and enantioselectivities (up to >99% ee) using hybrid amide-based Cinchona alkaloids. Our method is characterized by low catalyst loading (0.5 mol %) and short reaction times. Moreover, the epoxidation process can be carried out in 10 cycles, without further catalyst addition to the reaction mixture. This methodology significantly enhance the scale of the process using very low catalyst loading.

Organocatalytic Enantioselective γ-Elimination: Applications in the Preparation of Chiral Peroxides and Epoxides

An organocatalyzed enantioselective γ-elimination process has been achieved and applied in the kinetic resolution of peroxides to access chiral peroxides and epoxides. The reaction provided a pathway for the preparation of two useful synthetic and biologically important structural motifs through a single-step reaction. A range of substrates has been resolved with a selectivity factor up to 63. The obtained enantioenriched peroxides and epoxides allowed a series of transformations with retained optical purities.

Ligand regulation for manganese-catalyzed enantioselective epoxidation of olefins without acid

A novel manganese catalyst bearing an l-proline-derived N4 ligand has been developed for enabling acid-free asymmetric epoxidation of olefins with tert-butyl hydroperoxide as the oxidant. A variety of olefins that are well-matched in size with the ligand

The Synthesis of Hydrobenzoin-Based Monoaza Crown Ethers and Their Application as Recyclable Enantioselective Catalysts

Abstract: New recyclable monoaza-15-crown ethers have been synthesized starting from (R,R)-(+)- and (S,S)-(?)-hydrobenzoin. These macrocycles proved to be efficient and reusable phase transfer catalysts in a few asymmetric reactions under mild conditions.

Visible-Light-Driven Epoxyacylation and Hydroacylation of Olefins Using Methylene Blue/Persulfate System in Water

A visible-light-driven strategy for hydroacylation and epoxyacylation of olefins in water using methylene blue as photoredox catalyst and persulfate as oxidant is reported. In this unprecedented unified approach, two different transformations are accomplished using only one set of reagents. The method has a broad scope spanning a range of aromatic and aliphatic aldehydes as well as conjugated and nonconjugated olefins to deliver ketones and epoxyketones from abundant and inexpensive chemical feedstocks.

Method for preparing epoxide through induction of visible light

The invention belongs to the technical field of organic synthesis and provides a method for preparing an epoxide through induction of visible light. The method comprises the following step: under thecondition that the visible light and a photosensitizer exist, by taking oxygen or air as an oxygen source or an oxidizing agent and taking a synthesized amidine derivative as a catalyst, performing areaction at the temperature of -40-50 DEG C for 36h-192h, so that olefin is directly oxidized into the corresponding epoxide. The method is mild in reaction conditions, and the yield is as high as 94%or above, therefore, the method has good development value and application prospect.