95689-38-6

Basic information

• Product Name: 2-[3-(DIMETHYLAMINO)-1-METHOXY-2-PROPENYLIDENE]MALONONITRILE
• Synonyms: AURORA KA-6309;2-[3-(DIMETHYLAMINO)-1-METHOXY-2-PROPENYLIDENE]MALONONITRILE;(E)-2-(3-(Dimethylamino)-1-methoxyallylidene)malononitrile;2-(3-DIMETHYLAMINO-1-METHOXY-ALLYLIDENE)-MALONONITRILE;1,1-Dicyano-2-methoxy-4-dimethylamino-1,3-butadiene;2-[3-(DiMethylaMino)-1-Methoxy-2-propen-1-ylidene]-propanedinitrile;Propanedinitrile, 2-[3-(dimethylamino)-1-methoxy-2-propen-1-ylidene]-
• CAS NO: 95689-38-6
• Molecular Formula: C9H11N3O
• Molecular Weight: 177.2
• Product Categories: blocks;BuildingBlocks;Aliphatics;Amines;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 95689-38-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 130°
• Boiling Point: 130°C
• Flash Point: 149.2 °C
• Appearance: /
• Density: 1.078
• Vapor Pressure: 0.000268mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Dichloromethane
• PKA: 8.21±0.70(Predicted)
• CAS DataBase Reference: 2-[3-(DIMETHYLAMINO)-1-METHOXY-2-PROPENYLIDENE]MALONONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(DIMETHYLAMINO)-1-METHOXY-2-PROPENYLIDENE]MALONONITRILE(95689-38-6)
• EPA Substance Registry System: 2-[3-(DIMETHYLAMINO)-1-METHOXY-2-PROPENYLIDENE]MALONONITRILE(95689-38-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 95689-38-6(Hazardous Substances Data)

Usage

Chemical Properties

Orange Solid

Uses

Intermediate in the synthesis of antitumor agent Gimeracil (G378000).

InChI:InChI=1/C9H11N3O/c1-12(2)5-4-9(13-3)8(6-10)7-11/h4-5H,1-3H3/p+1/b5-4+

Upstream product

• 67-56-1 methanol 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 78-39-7 Triethyl orthoacetate 
• 109-77-3 malononitrile 
• 5515-16-2 2-(methoxyethylidene)propanedinitrile 

Downstream Products

• 21642-98-8 4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 98651-70-8 2-amino-4-methoxypyridine-3-carbonitrile 
• 98645-43-3 2-chloro-3-cyano-4-methoxypyridine 
• 98645-42-2 2-bromo-4-methoxypyridine-3-carbonitrile 
• 902171-51-1 2-methyl-4-methoxy-nicotinonitrile 
• 902171-52-2 1,4-dihydro-2-methyl-4-oxo-nicotinic acid 
• 902171-53-3 1,4-dihydro-1,2-dimethyl-4-oxo-nicotinic acid 
• 21642-98-8 2-hydroxy-4-methoxypyridine-3-carbonitrile 
• 1097202-23-7 3-amino-N-(4-chlorophenyl)-4-methoxythieno[2,3-b]pyridine-2-carboxamide 
• 1097202-26-0 3-(4-chlorophenyl)-9-methoxypyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-4(3H)-one 
• 1097202-27-1 2-(2-oxo-2-(4-phenylpiperazin-1-yl)ethylthio)-4-methoxypyridine-3-carbonitrile 
• 338773-61-8 ethyl 3-amino-4-methoxythieno[2,3-b]pyridine-2-carboxylate 
• 1097202-32-8 (3-amino-4-methoxythieno[2,3-b]pyridin-2-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone 
• 1097202-33-9 (3-amino-4-methoxythieno[2,3-b]pyridin-2-yl)(phenyl)methanone 

Relevant articles and documents

DIVALENT NUCLEOBASE COMPOUNDS AND USES THEREFOR

Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.

INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention relates to novel indole and benzoxazine derivatives which are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 ("mGluR2") and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.

IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

The present invention relates to novel compounds, in particular novel imidazo[1,2-a]piridine derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors - subtype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.