95891-30-8

Usage

Uses

Used in Pharmaceutical Industry:
6-Hydroxynicotinonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and improve existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Hydroxynicotinonitrile serves as an intermediate in the production of agrochemicals, aiding in the creation of effective compounds for agricultural applications.
Used in Research and Laboratory Experiments:
6-Hydroxynicotinonitrile is utilized as a research compound, facilitating scientific studies and experiments that explore its properties and potential applications in various fields.

Upstream product

• 33630-94-3 5-amino-2-hydroxypyridine 
• 151-50-8 potassium cyanide 
• 4214-73-7 6-aminonicotinonitrile 
• 106853-78-5 6-ethoxy-nicotinonitrile 
• 20511-12-0 2-amino-5-iodopyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 100-54-9 pyridine-3-carbonitrile 

Downstream Products

• 160906-98-9 6-chloro-5-nitro-3-pyridinecarbonitrile 

Relevant academic research and scientific papers

(AZA)INDAZOLYL-ARYL SULFONAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS

The invention provides (aza)indazolyl-aryl sulfonamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting GCN2 activity.

Synthesis of a series of iridium complexes bearing substituted 2-pyridonates and their catalytic performance for acceptorless dehydrogenation of alcohols under neutral conditions

A series of Cp*Ir complexes bearing 5- and 4,5-substituted 2-pyridonate ligands have been synthesized and their catalytic performance for acceptorless dehydrogenation of alcohols has been investigated under neutral conditions. Electron-withdrawing groups such as methoxycarbonyl, trifluoromethyl, cyano, and nitro groups at the 5-position promoted the acceptorless dehydrogenation of 1-phenylethanol, whereas electron-donating methyl group at the 5-position retarded the reaction. Furthermore, introduction of methyl group at the 4-position improved the catalytic performance. Thus, Cp*Ir(5-trifluoromethyl-4-methyl-2-pyridonate)Cl (2bc) exhibited the highest catalytic performance among the complexes examined, and also showed good catalytic performance for acceptorless dehydrogenation of primary alcohols.

Practical synthesis of (6-chloro-3-pyridyl)methylamine by highly selective hydrogenation of 6-chloro-3-pyridinecarbonitrile with improved Raney nickel catalyst

A practical synthesis of (6-chloro-3-pyridyl)methylamine (1), one of the key intermediates of neo-nicotinoid insecticides, by a highly selective hydrogenation of 6-chloro-3-pyridinecarbonitrile (4) is described. The use of an improved Raney nickel catalyst, prepared from an alloy of low nickel content (Ni 38%, A1 62%) and subjected to heat treatment in water (98 °C, 2 h) after leaching of aluminum, was highly effective for the selective hydrogenation of 4. The hydrogenation of 4 using this catalyst was carried out in EtOH-H2O [6:1 (v/v)] and NH3 at 50 °C and 1.2-1.4 kg cm-2 hydrogen pressure to give 1 in 86% yield and 3-pyridylmethylamine, a dechlorinated by-product, in 2% yield.