958993-45-8Relevant academic research and scientific papers
Nickel-Catalyzed Decarboxylative Alkylation of Aryl Iodides with Anhydrides
Chen, Hui,Hu, Lu,Ji, Wenzhi,Yao, Licheng,Liao, Xuebin
, p. 10479 - 10485 (2018/10/24)
We present the anhydride-based decarboxylative alkylation of aryl iodides catalyzed by nickel. This method of decarboxylative coupling works with a broad scope of aliphatic carboxylic anhydrides and tolerates synthetically useful aromatic substituents. Assisted by a redox system of pyridine N-oxide and zinc additives, the current reaction occurs under mild conditions and without the assistance of photocatalyst. Notably, this method features high chemoselectivity toward alkyl migration with mixed aliphatic/aromatic anhydrides. Thus, it provides a powerful synthetic tool to modify high-valued aliphatic carboxylic acids by converting them into mixed anhydrides using readily available aryl carboxylic acids such as p-toluic acid. We propose a catalytic cycle that involves the key steps of free radical-based decarboxylation and subsequent alkyl transfer to nickel that precedes an oxidatively induced C-C reductive elimination from Ni(III).
Iron(III)-Catalyzed Ortho-Preferred Radical Nucleophilic Alkylation of Electron-Deficient Arenes
Yu, Fei,Wang, Ting,Zhou, Huan,Li, Yajun,Zhang, Xinhao,Bao, Hongli
supporting information, p. 6538 - 6541 (2017/12/26)
The untraditional iron-catalyzed, ortho-preferred, radical alkylation of electron-deficient (hetero)arenes is reported. A variety of electron-deficient arenes were shown to react with various primary alkyl sources, producing the alkylated (hetero)arenes in good yields. This reaction might be an alkyl radical, nucleophilic aromatic substitution reaction, rather than the traditional electrophilic Friedel-Crafts reaction. HOMO-LUMO analysis and DFT studies on the key transition states underlying the regioselectivity are consistent with the observed reactions and the conclusions.
Multiple Melting Behaviour in Square-planar trans-Bis-(1-p-n-alkylphenylbutane-1,3-dionato)copper(II) - The Effect of Alkyl Chain Length
Ohta, Kazuchika,Jiang, Guang-Jie,Yokoyama, Masaaki,Kusabayashi, Shigekazu,Mikawa, Hiroshi
, p. 283 - 294 (2007/10/02)
The title complexes having different n-alkyl groups from methyl to dodecyl have synthesized.All these complexes exhibit solid polymorphism.The number of polymorphs depends on the length of the alkyl chain: two for n (the number of carbon atoms) = 0-2, three for n = 3-5 and 12, and four for n = 6-11, respectively.Each polymorphic form except those with the highest m.p.s. exhibits multiple melting behaviour: double melting for n = 0-5,8, and 12, and triple melting for n = 6-11 except 8.The m.p.s. of the complexes with alkyl groups of odd carbon atoms are higher than those with even atoms, while the respective ligand solids show the opposit e even-odd effect in their m.p.s.
